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丙型肝炎病毒核心区蛋白和细胞凋亡对细胞端粒酶活性的影响 被引量：1

The influence of HCV core protein and apoptosis on cellular telomerase activities
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摘要 丙型肝炎病毒(HCV)核心区编码的HCV-C蛋白维持病毒外形,还有较强的免疫调节功能,是细胞免疫的主要识别位点,在HCV致病过程中起着重要作用.端粒酶活性上调被认为是肿瘤发生的一种机制,HCV引发肝细胞癌(HCC)是否与上调肝细胞端粒酶活性有关?本实验拟对上述问题进行初步探讨,以部分阐明HCV导致HCC发生的机制.
作者 全俊 范学工 胡国龄 李宁 谭德明
机构地区 中南大学湘稚医院传染科
出处 《中华肝脏病杂志》 CAS CSCD 2004年第7期424-424,共1页 Chinese Journal of Hepatology
基金 湖南省卫生厅青年基金(B2003-029)
关键词 丙型肝炎病毒 核心区蛋白 细胞凋亡 细胞端粒酶活性 HCV-C蛋白 肝细胞癌 Hepatitis C virus Carcinoma, hepatocellular Core protein Apoptosis Telomerase
分类号 R735.7 [医药卫生—肿瘤]
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参考文献4

  • 1Mattson MP, Klapper W. Emerging roles for telomerase in neuronal development and apoptosis. J Neurosci Res, 2001, 63: 1-9.
  • 2Yang P, Becker D. Telomerase activity and expression of apoptosis and anti-apoptosis regulators in the progression pathway of human melanoma. Int J Oncol, 2000, 17: 913-919.
  • 3Zhang JX, Zhang ZK, Sheng HP, et al. Telomerase activity is not related to apoptosis in leukemic cell lines. Life Sci, 2000, 66: 1713-1723.
  • 4全俊,胡国龄,范学工,刘双虎,谭德明.丙型肝炎病毒核心区蛋白在HepG2细胞中的表达[J].中国现代医学杂志,2002,12(20):34-35. 被引量：10

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共引文献10

同被引文献9

  • 1Blasco MA. Telomeres and human disease: ageing, cancer and beyond. Nat Rev Genet, 2005, 6: 611-622.
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  • 4Baird DM. New developments in telomere length analysis. Exp Gerontol, 2005, 40: 363-368.
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  • 8Kiyozuka Y, Yamamoto D, Yang J, et al. Correlation of chemosensitiviy to anticancer drugs and telomere length, telomerase activity and telomerase RNA expression in human ovarian cancer cells. Antieaneer Res, 2000, 20(1A): 203.
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引证文献1

中华肝脏病杂志
2004年 第7期

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