摘要
目的 观察原发性高血压 (EH)患者血尿酸 (SUA)和肌酐 (Cr)值 ,探讨其相关性和临床意义。方法 用尿酸酶 POD终点法和苦味酸法 ,在全自动生化分析仪上测定SUA和Cr值。结果 2 80例EH患者伴发高尿酸血症(HUA) 119例 ,其Cr值 (131.4 0± 87.96 ) μmol/L ,明显高于非HUA者 (P <0 .0 1)。SUA和Cr值男性均高于女性 (P <0 .0 5 ) ,且随着年龄的增长和高血压分期的增加而明显升高 (P <0 .0 1) ,但Cr升高率明显迟后于HUA的发生率 (P<0 .0 1)。结论 ①EH患者Cr值与HUA关系密切 ;②SUA升高在Cr值升高之前 ;
Objective To determine the correlation of elevated serum uric acid(SUA)and creatinine(Cr)levels in patients with essential hypertension (EH).Methods SUA and Cr in individuals with various degrees of EH(n=280)were measured by uric enzyme-POD terminal and picric acid assays with biochemical auto-analyzer.Results One hundred nineteen cases were accompanied with hyperuricemia in 280 patients with EH, their mean Cr value was(131.4±87.96)μmol/L, higher than that in the patients without hyperuricemia significantly(P< 0.05 ),and increased with the growth of age stages of hypertension(P<0.01).The increase of Cr value was slower than hyperuricemia incidence. Conclusion ①Cr values have close relation with hyperuricemia in patients with EH.②Cr values changes with SUA in concordance in patients with EH,and have close relation with age and clinical stages.③SUA is an early manifestation of impairment of renal function in patients with EH.
出处
《江西医学院学报》
2004年第5期65-67,共3页
Acta Academiae Medicinae Jiangxi
关键词
原发性高血压
血尿酸
血肌酐
essential hypertension
serum uric acid
creatinine
