摘要
应用聚合酶链反应技术检测186例鳞状上皮细胞肿瘤组织中HPV-16相关DNA的阳性率为:正常口腔上皮组织为5.9%(1/17),口腔扁平苔癣为16.9%(5/30),口腔鳞癌为33.3%(12/36),鼻腔内翻性乳头状瘤为42.9%(3/7),喉乳头状瘤为11.1%(1/9),喉鳞癌为20.0%(4/20),慢性宫颈炎为27.3%(9/33),宫颈鳞癌为67.6%(23/34)。结果提示:HPV-16感染可能在生殖道及其他部位(口腔、喉、鼻腔)等部位癌前变及癌变病因学中起一定作用。
We examined 186 tissue samples of various squamous epithelium malignancies for the presence of human papi!lomavirus type16(HPV-16)DNA using polymerase chain reaction(PCR)technique.HPV-16DNA were found in 5.9%normal oral epithelium tissues(1/17).16.7%oral lichen planus(5/30).33.3%squamous epithelium carcinomas of the cavity(12/36),42.9%inverted papillomas of the nose(3/7),11.1%laryngeal papillomas(1/9),20.09 squamous cell carcinomas of the larynx(4/20),27.3%chronic cervititis(9/33)and 67.6%squanous cell carcinomas of the cervix.These results implied an etiological role of HPV-16 infections in precancer(intraepithelial neoplasia)and squamous cell carcinomas of the genital tract and other sites oral cavity,larynx,nasal cavity.
作者
赵文先
刘学锋
杨平
伍欣星
丁晓华
刘薇茜
Zhao Wenxian;Liu Xuefeng;Yang Ping(Department of Molecular Biology,Virus Research Insititute,Hubei Medical University,Wuhan 430071.China)
基金
国家“七五”科技专题基金资助
关键词
上皮细胞癌
鳞癌
聚合酶链反应
carcinoma,squamous cell/AN
papillomaviruses/AN:gene amplification
