摘要
目的 :探讨 2型糖尿病 (DM)患者的肥胖子女与非肥胖子女的胰岛素分泌功能的 6个参数水平的变化。方法 :以 2型糖尿病患者的 2 3名非肥胖子女为A组 ,18名肥胖子女为B组 ,对照组用 2 7名健康体检者 ,行简化的口服葡萄糖耐量试验 (OGTT) ,测空腹血糖和胰岛素 ,服糖后 2h血糖和胰岛素 ,应用稳态模式胰岛素抵抗指标 (HOMA -IR)作为胰岛素抵抗指标 ,用稳态模式胰岛 β细胞功能指数 (HBCI)作为胰岛素分泌指标 ,对三组的这些指标进行对比分析。结果 :与对照组比较 ,A组空腹血糖相对升高 (P <0 0 5 ) ,HBCI降低 (P <0 0 5 ) ,B组空腹血糖升高 (P <0 0 5 ) ,服糖后 2h血糖升高 (P <0 0 5 ) ,HBCI降低 (P <0 0 1) ,HOMA -IR升高(P <0 0 5 )。结论 :2型DM患者的非肥胖子女在出现糖耐量减低前存在胰岛素分泌功能减退 ,肥胖子女减退更明显。
Objective To investigate the disturbance of insulin-secretion function in the offsprings of patients with type Ⅱ diabetes. Methods Blood sugar (with oxidase method) and insulin (with RIA) levels were measured after overnight fasting and repeatedly measued 2h after 75g glucose per oral in the following subjects: ① Group A, 23 non-obese offsprings of type Ⅱ diabetics ② group B, 18 obese offsprings (BMI≥25kg/m 2) and ③ 27 controls. Homeostatic model assessment-insulin resistance (HOMA-IR) and β-cell function index (HCI) were calculated from the data (glucose and insulin levels) obtained. Results For Group A subjects, the fasting blood sugar (FPG) levels were significantly higher and HBCI significantly lower than those in te controls (both P<0.05). For Group B obese subjects, in addition to the above two parameters (with HBCI P<0.01), 2h PG levels as well as HOMA-IR were also significantly higher (both P<0.05). Conclusion Present study showed that in the offsprings of diabetics, HBCI was already lowered before definite impaired glucose tolerance (IGT) could be demonstrated, especially in the obese ones.
出处
《放射免疫学杂志》
CAS
2004年第5期343-344,共2页
Journal of Radioimmanology
