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联合应用卡介苗有效成分——罗莫肽和CpG-ODN刺激人PBMC分泌细胞因子 被引量：2

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作者 张晓文 王立新 姚茂银 肖家全
机构地区 东南大学基础医学院病原生物学与免疫学系 东南大学附属中大医院泌尿外科
出处 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2004年第5期602-603,共2页 Chinese Journal of Cellular and Molecular Immunology
基金 江苏省社会发展基金资助项目 (No .BS2 0 0 1 0 50 4 )
关键词 BCG 罗莫肽 CPG寡核苷酸 人外周血单个核细胞 细胞因子 免疫调节
分类号 R392.12 [医药卫生—免疫学]
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参考文献10

  • 1Alexandroff AB, Jackson AM, O' Donnell MA, et al. BCG immunotherapy of bladder cancer: 20 years on[J]. Lancet, 1999, 353: 1689- 1694.
  • 2Lamm DL, Thor DE, Harris SC, et al. Bacillus Calmette-Guerin immunotherapy of superficial bladder cancer[ J]. J Urol, 1980, 124: 38-40.
  • 3Azuma I, Seya T. Development of immunoadjuvants for immunotherapy of cancer[J]. Iht Immunopharmacol, 2001, 7: 1249 - 1259.
  • 4Ueda H, Yamazaki M. Induction of tumor necrosis factor-a in solid tumor region by the orally administered synthetic muramyl dipeptide analogue, romurtide[J]. Int Immunopharmacol, 2001, 1:97-104.
  • 5Hartmann G, Weeratna RD, Ballas ZK, et al. Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo[J]. J Immunol, 2000, 164:1617 -1624.
  • 6Hayashi A, Doi O, Azuma I, et al. Immunofriendly use of BCG-CWScell wall skeleton remarkably improves the survival rate of various cancer patients[J]. Proc Jpn Acad, 1998, 74(B): 50 -55.
  • 7Zlotta AR, Van-Vooren JP, Denis O, et al. What are the immunologically active components of bacille Calmette-Guerin in therapy of superficial bladder cancer? [J]. Int J Cancer, 2000, 87:844 -852.
  • 8Luo Y, Chen X, O'Donnell MA. Role of Th1 and Th2 cytokines in BCG-induced IFN-gamma production: cytokine promotion and simulation of BCG effect[J]. Cytokine, 2003, 21: 17 -26.
  • 9Krieg AM, Yi AK, Matson S, et al. CpG motifs in bacterial DNA trigger direct B-cell activation[ J]. Nature, 1995, 374: 546.
  • 10Davila E, Celis E. Repeated administration of cytosine-phosphrothiolated guanine-containing oligonucleotide together with peptide/protein immunization results in enhanced CTL responses with anti-tumor activity[J]. J Immunol, 2000, 165: 539 -547.

同被引文献23

  • 1MORALES A,EIDINGER D,BRUCE A W.Intracavitary Bacillus Calmette-Guerin in the treatment of superficial bladder tumours[J].J Urol,1976,116:180-183.
  • 2SROTHENFUSSER S,TUMA E,ENDRE S.Plasmacytoid dendritic cell:the key to CpG[J].Human Immunol,2002,63:1111-1119.
  • 3ZHU F G,MARSHALL J S.CpG-containing oligodeoxynucleotides induce TNF-alpha and IL-6 production but not degranulation from murine bone marrow-derived mast cells[J].J Leukoc Biol,2001,69:253-262.
  • 4ZHANG S D,LIU G,XIA X Q."Meshed-Bag Gathered-Bunch" method for solid-phase synthesis of small molecular diverse compounds[J].J Combin Chem,2002,4:131-137.
  • 5HIROSHI U,MASATOSHI Y.Induction of tumor necrosis factor-α in solid tumor region by the orally administered synthetic muramyl dipeptide analogue,romurtide[J].Intern Immunopharmacol,2001,1:97-104.
  • 6DOU J,CHEN G B,ZHAO F S,et al.Preliminary study on mouse interleukin 21 application in tumor gene therapy[J].Cell & Molec Immunol,2004,1:388-396.
  • 7DOU J,LIU K Z,CHEN Z,et al.Study on peripheral blood mononuclear cell (PBMC) proliferation responses to different HCV antigens in patients with hepatitis C[J].Immunolog J,1999,15:5-10.
  • 8LAMM D L,THOR D E,HARRIS S C,et al.Bacillus Calmette-Guerin immunotherapy of superficial bladder cancer[J].J Urol,1980,124:38-40.
  • 9LAMM D L.BCG in perspective:advances in the treatment of superficial bladder cancer[J].Euro Urol,1995,27 (Suppl4):2-8.
  • 10CHINA J L,KADHIM S A,BATISLAM E,et al.Mycobacterium cell wall:an alternative to intravesical Bacillus Calmette-Gurein (BCG)therapy in orthotopic murine bladder cancer[J].J Urol,1996,156:1189-1193.

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细胞与分子免疫学杂志
2004年 第5期

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