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α_1-肾上腺素受体的研究进展 被引量：3

Advances in the Research on Alpha1-Adrenergic Receptors
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摘要 α1 肾上腺素受体介导了机体内源性儿茶酚胺的大多数反应 ,参与了机体的许多基本生理过程 ,诸如交感神经传导、心脏收缩、血管张力、肝脏代谢以及泌尿生殖系统平滑肌活动的调控。本文综述了近年来关于α1 肾上腺素受体的亚型、分布及信号转导等方面的进展 ,以期为α1 肾上腺素受体的药理、生理及病理生理学作用提供更深入的认识。 Alpha1-adrenergic receptors (ARs) mediate some of the main actions of the natural catecholamines, participate in many essential physiological processes, such as sympathetic neurotransmission, cardiac contraction, control of vascular tone, modulation of hepatic metabolism, and regulation of smooth muscle activity in the genitourinary system. This article reviews the recent progress in subtypes, subcellular localization and signal transduction of alpha1-adrenergic receptors, to provide insights into the pharmacological, physiological and pathophysiological roles of the alpha1-adrenergic receptors.
作者 何星颖 石学银
机构地区 第二军医大学长征医院麻醉科
出处 《医学分子生物学杂志》 CAS CSCD 2004年第5期313-315,共3页 Journal of Medical Molecular Biology
关键词 Α1-肾上腺素受体 肝脏代谢 心脏收缩 泌尿生殖系统 血管张力 研究进展 交感神经 生理过程 信号转导 调控 alpha1-adrenergic receptors signal transduction subcellular localization
分类号 R541 [医药卫生—心血管疾病] R977 [医药卫生—药品]
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参考文献12

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同被引文献22

  • 1李艳芳,杨洁芹.血管紧张素ⅡAT_1与AT_2受体的交互作用及信号转导[J].中华老年心脑血管病杂志,2000,2(6):423-426. 被引量：4
  • 2黄灵芝.雄激素受体-共调节因子作用位点将成为新药研发的靶点[J].国外医学（药学分册）,2005,32(5):350-351. 被引量：1
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  • 7[7]Jerez S,de Bruno MP,Coviello A.Cross talk between angiotensin Ⅱ and alpha 1 adrenergic receptors in rabbit aorta:role of endothelium[J].J Cardiovasc Pharmacol,2004,43(3):402-409.
  • 8[8]Jerez S,de Bruno MP,Coviello A.Endothelium-dependent desensitization to angiotensin Ⅱ in rabbit aorta:the mechanisms involved[J].Can J Physiol Pharmacol,2001,79:481-489.
  • 9[9]Crespo MJ.Interaction between AT1 and α1-adrenergic receptors in cardiomyopathic hamsters[J].J Card Fail,2000,6:257-263.
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引证文献3

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医学分子生物学杂志
2004年 第5期

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