摘要
目的 研究影响脑转移瘤手术治疗预后的因素。方法 回顾性分析 35例脑转移瘤外科治疗的临床资料。根据治疗方法将其分成 6组 ,统计分析各组治疗结果。结果 1年生存率为 4 8.6 % ,2年生存率为 14 .3% ,5年生存率为 2 .9%。手术加放疗组平均生存时间为 (14 .6± 1.8)个月 ,显著高于单纯手术组的 (8.3± 1.9)个月 (P <0 .0 5 )。手术加化疗组平均生存时间为 (13.0± 3.5 )个月 ,与单纯手术组无显著差异 (P >0 .0 5 )。结论 脑转移瘤经外科治疗后预后仍差。手术后结合放疗优于单纯手术 ,而手术后化疗不能有效地延长脑转移瘤患者的生存时间。
Objective To evaluate the prognostic factors in surgical treatment of brain metastases. Methods 35 cases of brain metastases were reviewed retrospectively. Of 35 cases, 16 were male and 19 were female, age ranged from 24 to 73 years. All cases were divided into 6 groups by means of treatment modalities. Treatment results were analysed. Results The 1, 2 and 5-year survival rates were 48.6%, 14.3% and 2.9% respectively. Survival in the group with treatment by surgery plus radiation therapy [(14.6±1.8) months] was significantly longer than that with treatment by surgery alone[(8.3±1.9) months](P< 0.05 ). There was no significant difference between the survival in group with treatment by surgery plus chemotherapy [(13.0± 3.5 ) months] and that by surgery alone [(8.3±1.9) months](P>0.05). Conclusions The prognosis of brain metastases with surgical treatment is poor. Patients treated by surgery combined with radiation therapy lived longer than those who underwent surgery alone. Chemotherapy following surgery helped little to patients with brain metastases.
关键词
脑转移瘤
手术
放疗
化疗
brain metastases
surgery
radiation therapy
chemotherapy
