摘要
在对GenBank和EMBL数据库中登录的昆虫抗微生物肽 (antimicrobialpeptide,AMP) ,即昆虫抗菌肽 (antibacterialpeptide)和抗真菌肽 (antifungalpeptide ,AFP)进行归类整理的基础上 ,对天蚕素族 (cecropins)抗菌肽结构与功能的关系及人工改造的分子设计策略 ,特别是对目前新发现的一些昆虫抗真菌肽的已知结构与功能关系的研究进展、存在问题等进行了简要介绍和分析 ,为从事昆虫抗微生物肽的理论研究和发展新型抗生素药物提供了必要的信息。
Insect antimicrobial peptides (AMP), including antibacterial peptides and antifungal peptides (AFP), are classified based on the accession sequences registered in GenBank and EMBL databases, and the relationships between the molecular structure and function of cecropin family and their molecular design strategies were summarized.The research progress and the challenging problems concerning the relationships between the known molecular structure and function of some newly identified antifungal peptides were introduced and analyzed. Such information will be useful not only for the basic studies of antimicrobial peptides but also for developing novel antibiotic drugs in the near future.
出处
《昆虫学报》
CAS
CSCD
北大核心
2004年第5期659-669,共11页
Acta Entomologica Sinica
基金
国家自然科学基金项目 ( 3 0 170 14 6)
广东省自然科学基金项目 ( 0 10 2 94)
广东省科技计划项目 ( 2 0 0 3C10 40 42 )
关键词
昆虫
抗菌肽
抗真菌肽
分子设计
Insect
antibacterial peptide
antifungal peptide
molecular design
