摘要
对紫草素合成中间体1,4,5,8-四甲氧基萘-2-甲醛的制备工艺进行了改进,由萘茜在溴化四丁基铵催化下进行还原甲基化的收率由文献报道的44%提高到90%,标题化合物总收率72%(以对二甲氧基苯计)。
The synthesis of 1,4,5,8-tetramethoxynaphthalene-2-carboxaldehyde, an intermediate of shikonin wasinvestigated. The yield of the tandem reduction and methylation of 5,8-dihydroxy-1,4-naphthoquinone was increased from44% to 90% in the presence of phase transfer catalyst tetrabutylammonium bromide. The overall yield of title compoundwas 72% based on 1,4-dimethoxybenzene.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2004年第10期583-585,共3页
Chinese Journal of Pharmaceuticals
基金
上海-SK研究与发展基金(2003014-h)
