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噬菌体展示肽库技术应用的研究进展 被引量：7

Advancement phage display peptide library technology
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摘要 噬菌体展示肽库技术是一种新的肿瘤筛选技术 ,它将随机多肽文库表达于丝状噬菌体的表面 ,使高通量筛选多肽配体变得容易些。该技术在研究蛋白质之间的相互作用、寻找肿瘤特异性抗原和治疗性靶肽以及在新型诊断试剂和疫苗研制中都有重要用途。 Phage display peptide library technology is based on expressing recombinant random peptides on the surface of filamentous phage. It is a new approach through high-throughput selection of peptide ligands of diversity facilitated. The technique is widely used in exploring protein-protein interactions, finding specific antigens of tumor, cancer targeting therapeutic peptides, new diagnostic agents, and vaccine development.
作者 李芳秋 朱扣军 武建国
机构地区 南京军区南京总医院南京大学医学院临床学院解放军医学检验中心
出处 《医学研究生学报》 CAS 2004年第9期843-846,共4页 Journal of Medical Postgraduates
关键词 噬菌体展示肽库 蛋白质相互作用 肿瘤靶肽 Phage display peptide library Protein-protein interactions Cancer targeting therapeutic peptides
分类号 Q939.48 [生物学—微生物学]
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参考文献25

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  • 9李芳秋,严明,武建国.亲环素A抗原表位氨基酸序列及三维结构研究[J].医学研究生学报,2001,14(3):189-191. 被引量：2
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二级参考文献9

  • 1王林发,郁萌.利用丝状噬菌体展示技术进行抗原决定族图谱及其基因工程的研究[J].生物工程学报,1996,12(3):235-246. 被引量：4
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医学研究生学报
2004年 第9期

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