摘要
目的:探讨脾气虚胃溃疡证病结合模型中大脑神经内分泌免疫网络(NEI)的变化及其作用。方法:采用免疫组织化学方法和放射免疫测定技术。结果:免疫组织化学检测结果为,脾气虚胃溃疡过程中大脑神经细胞分泌生长抑素、P物质、血管活性肠肽、白介素-2的活性均显著增强;放射免疫测定也显示下丘脑SST的分泌活性增强。结论:(1)大鼠实验性脾气虚胃溃疡期间,大脑局部神经、内分泌及免疫活动均发生了一定程度的变化。(2)高级神经中枢参与脾气虚合并胃溃疡疾病过程的调节。
Objective: To explore the changes of neuroendocrine-immuno network in brain during experimental spleen-deficiency combined with gastric ulcer syndrome. Methods : Immunohistochemistry and radioimmunoassay were used. Results : Immunohistochemical study showed that the level of somatostatin(SST), substance P(SP), vascular active intestinal peptide (VIP), interleukin-2 (IL-2) secreted by neural cells in brain was higher during 4 and 14 days in spleen-deficiency combined with gastric ulcer. The level of SST in plasm and hypothalamus was also higher by radioimmunoassay. Conclusion :(1)The function of neuroendocrine-immuno has some changes in brain during experimental spleen-deficiency combined with gastric ulcer in rats. (2)Advanced neural center participates in the regulation during spleen-deficiency combined with gastric ulcer.
出处
《解剖学杂志》
CAS
CSCD
北大核心
2003年第6期537-542,共6页
Chinese Journal of Anatomy
