摘要
目的 :分析胃腺癌组织的低密度脂蛋白受体 (LDLR)活性 ,研究其与癌组织分化程度的关系。方法 :以12 5I LDL为配体 ,采用受体放射性配体结合分析法测定胃腺癌及其周边组织LDLR活性。结果 :胃腺癌组织与其周边正常组织LDLR活性差异明显 (P <0 .0 1) ,但LDLR的亲合性和特异性无明显改变 ;分化好与分化差的腺癌组织的LDLR活性差异显著 (P <0 .0 1)。结论 :胃腺癌组织LDLR活性明显增高 ,组织分化越低 。
Objective:To investigate the activity of LDL receptor (LDLR) in gastric adenocarcinoma and analyze the relation between LDLR and the tissue differentiated degree of gastric adenocarcinoma.Methods:Using 125 I-LDL as the radioligand and method of receptor radioligand binding analysis to determine the LDLR activity in gastric careinoma tissue.Results:The LDLR activity in gastric adenocarcinoma was obviously higher than the normal gastric tissues,there was significantly statistical difference(P<0.01),but affinity and specificity of LDLR didn’t obviously change.Conclusion:The LDLR activity in the gastric adenocarcinoma is obviously higher,the lower the differentiated degree of gastric adenocarcinoma tissues,the higher the LDLR activity.The relationship between the LDLR and the differentiated degree of gastric adenocarcinoma tissues had negative correlation.
出处
《中国现代普通外科进展》
CAS
2004年第4期215-216,共2页
Chinese Journal of Current Advances in General Surgery
基金
山东省科技厅科研基金资助项目 ( 971164 60 7)
关键词
胃肿瘤
腺癌
受体
LDL
Stomach neoplasms·Adenocarcinoma·Receptors,LDL
