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预定位技术在肿瘤治疗中的应用 被引量：1

Application of technology pretarget in tumor
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摘要 预定位技术是在放射免疫治疗基础上发展起来的一种新的肿瘤治疗方法 ,具有与靶抗原亲和力高、毒性低、血清清除快等优点 ,对于实体瘤有很好的疗效。目前的预定位技术主要有生物素和亲合素的预定位模式和双特异性抗体的预定位模式两种。现综述预定位技术的产生、现状及展望。
作者 许元生 杨纯正
机构地区 中国医学科学院血液学研究所药理室
出处 《国外医学（肿瘤学分册）》 2004年第7期511-513,共3页 Foreign Medical Sciences (Cancer Section)
关键词 放射免疫疗法 生物素 抗体 双特异性
分类号 R730.5 [医药卫生—肿瘤]
  • 相关文献

参考文献14

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同被引文献30

  • 1叶靖,许乙凯.生物素/亲和素系统用于活体分子成像现状[J].国外医学（临床放射学分册）,2005,28(4):193-195. 被引量：1
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  • 8Hnatowieh D J, Virzi F, Rusekowski M. Investigation of avidin and biotin for imaging applications[ J ]. J Nucl Med, 1987,28 (8) :1294- 1302.
  • 9Zhang M,Zhang Z,Garmestani K,et at. Pretarget radiotherapy with an anti-CD25 antibody-streptavidin fusion protein was effective in therapy of leukemia/lymphoma xeuografts[ J ]. Proc Natl Acad Sci USA ,2003,100(4) : 1891-1895.
  • 10Graves S S, Dearstyne E, Lin Y, et al. Combination therapy with pretarget CCA9 radioimmunotherapy and gerncitabine prolongs tumor doubling timein amurine xenograftmod elofcolon cancermore effectively than either monotherapy [ J ]. Clin Cancer Res, 2003,9 (10) : 3712-3721.

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国外医学（肿瘤学分册）
2004年 第7期

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