期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

一氧化氮在创伤伤口愈合中的作用研究进展 被引量：1

Advances on function of NO in trauma healing
暂未订购
导出
摘要 一氧化氮 (NO)是在 1 976年发现的一种新型小分子物质 ,其半衰期短 ,化学性质活泼 ,广泛存在于生物体内 ,参与血管、神经系统和免疫功能等许多重要的生物调节作用。越来越多的研究表明 ,创伤愈合中细胞增殖期间的巨噬细胞、纤维母细胞、角化细胞等都存在NO的合成并影响着伤口的愈合。相反在NO合成受到抑制的伤口愈合中则存在伤口愈合延迟的现象 ,过度纤维化中减少NO的合成则可以预防瘢痕的形成。NO在创伤伤口愈合中的作用已逐渐受到了人们的重视。 NO was found in 1976 as one new small molecule,which exists in body widely and participate in many important bio modulation activity of blood,nerve and immune system.?It has a short half time,and is chemically very active.?More study showed that NO is synthesized in macrophages,fibroblasts and keratinocytes during healing of trauma.?On the contrary,the healing was retarded when the NO synthesis was inhabited.?In excess fibrosis,the decrease of NO synthesis could prevent the scar formation.?Function of NO in trauma healing has been recognized gradually by the people.
作者 邢叔星 尹志勇
机构地区 第三军医大学大坪医院野战外科研究所四室
出处 《创伤外科杂志》 2004年第4期309-311,共3页 Journal of Traumatic Surgery
关键词 一氧化氮 创伤愈合 精氨酸合酶 NO trauma healing arginine synthase
分类号 R641-01 [医药卫生—外科学]
  • 相关文献

参考文献23

  • 1杨力,郭树忠.成纤维细胞与创伤修复的生物学过程[J].中国临床康复,2002,6(4):470-471. 被引量：40
  • 2Frank S,Madlener M,Pfeilschifter J,et al.Induction of inducible nitric oxide synthase and its corresponding tetrahydrobiopterin-cofactor-synthesizing enzyme GTP-cyclohydrolase I during cutaneous wound repair[J].J Invest Dermatol,1998,111(6):1058-1064.
  • 3Stallmeyer B,Kampfer H,Kolb N,et al.The function of nitric oxide in wound repair:inhibition of inducible nitric oxide-synthase severely impairs wound reepithelialization[J].J Invest Dermatol,1999,113(6):1090-1098.
  • 4Frank S,Kolb N,Werner ER,et al.Coordinated induction of inducible nitric oxide synthase and GTP-cyclohydrolase I is dependent on inflammatory cytokines and interferon-gamma in HaCaT keratinocytes:implications for the model of cutaneous wound repair[J].J I
  • 5Christian WC,Kampfer H.Keratinocyte-derived chemotactic cytokines:expressional modulation by nitric oxide in vitro and during cutaneous wound repair in vivo[J].Biochemical and Biophysical Research Communications,2000,274(3):689-696.
  • 6Neil A,Salyapongse AN,Howard D.Altered connexin expression in nitric oxide synthase knockout mice:a potential mechanism for delayed wound healing[J].J Am College of Surgeon,2000,191(4):S80.
  • 7Witte MB,Thornton FJ,Tantry U,et al.L-Arginine supplementation enhances diabetic wound healing:involvement of the nitric oxide synthase and arginase pathways[J].Metabolism,2002,51(10):1269-1273.
  • 8Knowles RG,Moncada S.Nitric oxide synthases in mammals[J].Biochem J,1994,298(Pt2):249-258.
  • 9Ferrini MG,Vernet D,Magee TR.Antifibrotic role of inducible nitric oxideSynthase[J].Nitric Oxide,2002,6(3):283-294.
  • 10Buga GM,Wei LH,Bauer PM,et al.NG-hydroxy-L-arginine and nitric oxide inhibit Caco-2 tumor cell proliferation by distinct mechanisms[J].Am J Physiol,1998,275(4Pt2):R1256-1264.

二级参考文献19

  • 1宋慧锋,林子豪,刘宁飞,陈敏亮,朱晓海.人胎儿和成人皮肤及其创面愈合过程中转化生长因子-β的表达[J].中国组织工程研究与临床康复,2001,10(14):60-61. 被引量：6
  • 2郭爱华,柳大烈.胚胎无瘢痕愈合的调控机制研究:(I)成纤维细胞形态和生长动力学研究[J].中国组织工程研究与临床康复,2001,10(24):56-57. 被引量：7
  • 3CREIGHTON WM,TAYLOR A J, DICHEK DA, et al.Regional variability in the time course of TGF beta 1 expression,cellular proliferation and estracellular matrix expansion following arterial injury[J].Growth Factors,1997,14(4):297-306.
  • 4BAIRD A.The regulation of basic fibroblast growth factor(FGF-2) through limited bioavialability[A]// ZIEGLER TR, PIERCE GF,HEMDON DN,et al.Growth factors and wound healing, basic science and potential clinical application[M].New York:Springer Verlag,1997:27-36.
  • 5ORNITZ DM, WAKSMAN G.Fibroblast growth factor receptors[A]// ZIEGLER TR,PIERCE GF, HERNDON DN,et al.Growth factors and wound healing, basic science and potential clinical application[M].New York:Springer Verlag,1997:151-176.
  • 6KINGSNORTH AN, SLAVIN J.Peptide growth factors and wound healing[J]. J Surg (Br),1997,78(11):1286-1289.
  • 7MORI T, KAWARA S, SHINOZAKI M, et al. Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: A mouse fibrosis model[J]. J Cell Physiol, 1999,181(1):153-159.
  • 8CAILIT J,PIERSCHBACHER M,CLARK RAF.Expression of functional α 4β 1 by human dermal fibroblast to provisional[J].J Invest Dermatol,1993,100:323-328.
  • 9MURIR IFK,PADILLA LAMB A,STEWART E,et al. Growth inhibition of cultured fibroblasts by estracts from human dermis[J].Br J Plast Surg,1997,50:186-193.
  • 10KNOX P,CROOKS S,RIMMER CS.Role of fibronectin in the migration of fibroblasts into plasma clots[J].J Cell Biol,1986,102:2318-2323.

共引文献39

同被引文献10

引证文献1

二级引证文献2

创伤外科杂志
2004年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部