摘要
目的 研究153 Sm -EDTMP治疗肺癌、乳癌及前列腺癌骨转移所致骨痛的疗效。方法 静脉注射153 Sm -EDTMP ,给药剂量 18 5～ 3 7MBq/kg( 0 5～ 1 0mCi/kg)体重 ,每隔 1～ 2个月 1次注射。结果 肺癌、乳癌及前列腺癌153 Sm -EDTMP治疗骨痛的总有效率分别为 68 5 %、89 3 %及 10 0 % ,且乳癌和前列腺癌的疗效与肺癌相比有明显差异 (P <0 0 0 5 ) ,多数患者 ( 81 5 % )WBC或PLT一过性减少。结论 放射性核素治疗以成骨为主的骨转移灶 ,止痛效果明显 ,方法简便 。
Objective To investigate the clinical effect of 153 Sm-EDTMP treatment on pain palliation in the patients with bone metastasis of lung cancer, breast cancer or prostate cancer. Methods 166 patients with bone metastasis of cancers were intravenously injected 18.5～37 MBq/kg (0.5～1.0 mCi/kg ) body weight of 153 Sm-EDTMP, once a month or two months. Results The effective rate of pain palliation of 153 Sm-EDTMP treating bone metastasis of lung cancer, preast cancer and prostate cancer were 68.5%, 89.3% and 100%, respectively. The efficacious rate of pain palliation in breast and prostate cancers was significantly higher than that in lung cancer (P<0.005 ). 81.5% of patients had transient leukopenia or thrombocypenia after treatment. Conclusion Radionuclide 153 Sm-EDTMP treating bone metastases of cancers had the advantages of simplicity, less side effects and definite pain palliation effect.
出处
《中国医师杂志》
CAS
2004年第8期1024-1025,共2页
Journal of Chinese Physician
