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瘦素与骨质疏松研究进展 被引量：2

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摘要 研究表明原代培养的骨髓脂肪细胞有高水平的瘦素表达;瘦素可促进人骨髓基质细胞向成骨细胞分化,抑制其向脂肪细胞分化;另外,血瘦素水平影响老年人成骨细胞活性及胎儿的骨骼发育,这些均提示瘦素影响骨代谢。成骨细胞上有瘦素及其受体表达,表明瘦素可直接作用于骨。瘦素也可通过中枢抑制骨形成。瘦素并不影响骨吸收。瘦素在绝经后骨质疏松的发生中发挥一定作用,还可能介导了糖尿病相关性骨质疏松的发生。瘦素用于治疗骨质疏松的前景值得评价。
作者 李淑梅 张秀珍
机构地区 同济大学附属同济医院内分泌科
出处 《国外医学（内分泌学分册）》 2004年第4期227-229,共3页 Foreign Medical Sciences(Section of Endocrinology)
基金 国家自然科学基金资助项目(30070357)
关键词 瘦素 骨质疏松 骨髓 脂肪细胞 骨组织
分类号 R58 [医药卫生—内分泌]
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参考文献20

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同被引文献65

  • 1汪雷,韦永中,曹晓建,余利鹏.瘦素对骨代谢影响研究进展[J].国际骨科学杂志,2006,27(6):337-339. 被引量：6
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国外医学（内分泌学分册）
2004年 第4期

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