摘要
对于前列腺癌患者临床前期和无症状期 ,临床诊断往往缺少最有效的无创性检测方法。恶性肿瘤患者血循环中核酸含量明显高于正常人 ,研究证实其来源于肿瘤细胞 ,并且与原发肿瘤有着结构或功能上的某些一致性 ,因此循环核酸对肿瘤的早期发现和早期诊断及治疗都具有重要价值。近年细胞分子生物学技术的发展 ,循环核酸的检测成为可能 ,这方面的研究也成为热点 ,本文对国内外前列腺癌循环核酸的研究进展进行了综述。
A major problem for the early diagnosis of prostate cancer is the lack of clinically useful tests for screening a preclinical and asymptomic population without resort to invasive diagnostic procedures. Recent studies have demonstrated the possibility to detect genetic alterations in plasma or serum DNA from patients with prostate cancer or other cancers. Quantification and molecular event are associated with advanced stages and circulating tumor cells. These results indicate a new approach to the early diagnosis and monitoring of prostate cancer by non-invasive screening procedures based on the analysis of genetic changes in plasma.
出处
《中华男科学杂志》
CAS
CSCD
2004年第7期543-546,共4页
National Journal of Andrology
关键词
前列腺癌
循环核酸
肿瘤
prostate cancer
circulating DNA
tumor
