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白细胞介素-28和白细胞介素-29的研究进展 被引量：4

Progress on IL-28 and IL-29
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摘要 白细胞介素 2 8(IL 2 8A、IL 2 8B)和白细胞介素 2 9(IL 2 9)是一组由病毒或双链RNA诱导的多种细胞产生的新型白细胞介素 ,它们能结合一种由IL 1 0Rβ和IL 2 8Rα组成的异二聚体型Ⅱ类细胞因子受体 ,通过Jak STAT信号通路而发挥其抗病毒或其他防御功能。作者就IL 2 8与IL 2 9的分子结构、编码蛋白、受体与生物学活性等作一综述。 The three members of this newly identified cytokine family, termed IL 28A, IL 28B and IL 29, binds to a heterodimeric receptor, in which one subunit is a novel member of the class II cytokine receptor family(designated IL 28Rα) and the other is identical to the IL 10 receptor β(IL 10Rβ). These newly described cytokines are induced by virus infection or double stranded RNA and showed antiviral activity, and they activate the Janus kinases signal transducers and activators of transcription(Jak STAT) pathway. The receptor ligand system may contribute to antiviral or other defenses by a mechanism similar to, but independent of , type I interferons(IFN).
作者 李明才 何韶衡
机构地区 汕头大学医学院变态反应学与炎症学研究所
出处 《医学研究生学报》 CAS 2004年第7期641-643,共3页 Journal of Medical Postgraduates
关键词 白细胞介素-28A 白细胞介素-28B 白细胞介素-29 白细胞介素-10 干扰素 IL 28A IL 28B IL 29 IL 10 Interferon
分类号 R392.11 [医药卫生—免疫学]
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参考文献8

  • 1[1]Sheppard P, Kindsvogel W, Xu W et al. IL-28, IL-29 and their class Ⅱ cytokine receptor IL-28R[J]. Nature Immunol, 2003,4(1): 63-68.
  • 2[2]Kotenko SV, Gallagher G, Baurin VV et al. IFN-λs mediate antiviral protection through a distinct class Ⅱ cytokine receptor complex [ J ].Nature Immunol, 2003,4(1 ): 69-77.
  • 3[3]LaFleur DW , Nardelli B, Tsareva T et al. Interferon-kappa, a novel type I interferon expressed in human keratinocytes[ J ]. J Biol Chem,2001, 276(43) :39765-39771.
  • 4[4]Oritani K, Medina KL, TomiyamaY etal. Limitin: An interferon-like cytokine that preferentially influences B-lymphocyte precursors [ J ].Nat Med, 2000, 6(6): 659-666.
  • 5[5]Kotenko SV. Tne family of IL10-related cytokines and their and their receptors: related, but to what extent? [ J ] Cytokine Growth Factor Rev, 20]02,13(3): 223-240.
  • 6[6]Dumoutier L, Renauld JC. Viral and cellular interleukin-10(IL-l0)-related cytokines: from structures to functions [ J ]. Eur Cytokine Netw, 2002, 13(1): 5-15.
  • 7[7]Renauld JC. Class Ⅱ cytokine receptors and their ligands: key antiviral and inflammatory modulators[J]. Nature Rev Immunol, 2003,3(8):667 -676.
  • 8[9]Vilcek J. Novelinterferons[J]. Nature Immunol, 2003, 4(1) :8-9.

同被引文献57

  • 1郝京生,单保恩.白细胞介素-23的研究进展[J].国外医学（临床生物化学与检验学分册）,2005,26(6):335-337. 被引量：3
  • 2瞿少刚,张秀萍,陈群,刘仿.IL-24融合蛋白表达载体的构建及其对人小肠癌细胞的生长抑制作用[J].世界华人消化杂志,2006,14(5):497-501. 被引量：2
  • 3Sheppard P,Kindsvogel W,Xu W et al.IL-28,IL-29 and their class II cytokine receptor IL-28R[J].Nat Immunol,2003,4(1):63.
  • 4Kotenko S V,Gallagher G,Baurin V V,et al.IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex[J].Nat Immunol,2003,4(1):69.
  • 5Ferrantini M,Capone I,Belardelli F.Interferon-a and cancer:Mechanisms of action and new perspectives of clinical use[J].Biochimie,2007,89 (6～7):884.
  • 6Renauld J C.ClassⅡ cytokine receptors and their ligands:key antiviral and inflammatory modulators[J].Nature Rev Immunol,2003,3(8):667.
  • 7Ank N,West H,Bartholdy C,et al.Lambda interferon (IFN-lambda),a type III IFN,is induced by viruses and IFNs and displays potent antiviral activity against select virus infections in vivo[J].J Virol,2006,80(9):4501.
  • 8Dumoutier L,Lejeune D,Hor D,et al.Cloning of a new type II cytokine receptor activating signal transducer and activator of transcription (STAT)1,STAT2 and STAT3[J].Biochem J,2003,370(Pt 2):391.
  • 9Dumoutier L,Tounsi A,Michiels T,et al.Role of the interleukin (IL)-28 receptor tyrosine residues for antiviral and antiproliferative activity of IL-29/interferon-lambda 1:similarities with type I interferon signaling[J].J Biol Chem,2004,279(31):32269.
  • 10Vilcek J.Novel interferons[J].Nat Imnmnol,2003,4(1):8.

引证文献4

二级引证文献24

医学研究生学报
2004年 第7期

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