摘要
目的 探讨难治性癫痫发病机制 ,为寻找难治性癫痫新的治疗方法提供理论依据。方法 采用ELISA方法检测临床确诊为难治性癫痫的 12例患者血清及脑脊液P 蛋白 (P Glu proteis,PGP) ,并与用药物控制良好的 15例癫痫患者和 11例正常人比较 ,用OD值做为参数进行分析。结果 难治性癫痫组血清及脑脊液PGP明显高于癫痫组和正常对照组。结论 PGP可能是促成癫痫耐药的重要因素 ,并可作为癫痫患者耐药的一个客观指标。
Objective To investigate the pathogenesis of intractable epilepsy(IE), it provides the theory basis for new therapy methods of IE.Methods ELISA was used to test P-Glu-proleit(PGP) in the serum and CSF of IE patients(which had been diagnosed), and compared with epilepsy patients which reacted well to medicine and healthy subjects. Furthermore, OD was analysed as the parameter.Results The level of PGP in the serum and CSF in IE group were significantly higher than those in epilepsy group and normal control group.Conclusion PGP may be an important reason for contributing to epilepsy resistance to medicine, and it can be considered as an objective index of resistance to medicine in epilepsy patients.
出处
《中国实验诊断学》
2004年第3期279-281,共3页
Chinese Journal of Laboratory Diagnosis
