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胰岛激活蛋白促进小鼠生长的作用 被引量:2

The Effect of Islets-activating Protein on Enhancing Growth Rate of Mice
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摘要 在两次实验中给体重27~39g的成年雌性或雄性小鼠腹腔注射细菌源性胰岛激活蛋白(IAP)0.4或2μg/鼠。结果表明,注射IAP可使小鼠4周平均体增重比对照组提高44%~82%,胴体重量也有增加的趋势。胴体脂肪组织含量和比例明显增加(p<0.05),而胴体肌肉组织比例不受影响。注射IAP不影响动物的采食量,但增加脂肪存留,提示IAP可提高营养物质的利用率。 The adult male or female mice,with body weight 27~39 g,were abdominally injected with 0.4 μg/mouse or 2 μg/mouse bacteria-originated islets-activating protein(IAP)in two experiments.The results showed that the injection of IAP enhanced body-weight gain over a period of 4 weeks by 44%~82%,and tended to increase carcass weight.The weight and proportion of adipose tissue in the carcass were significantly increased(p<0.05)while the proportion of lean tissue to the carcass had no change.The injection of IAP did not affect feed intake,but increased fat retention,indicating that it improved the utilization efficiency of nutrients.
出处 《新疆农业科学》 CAS CSCD 2004年第4期193-195,共3页 Xinjiang Agricultural Sciences
基金 科技部重大基础研究前期研究专项(2002CCC0300)
关键词 胰岛激活蛋白 小鼠 促生长作用 脂肪 增重 islets-activating protein mice growth
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参考文献4

  • 1Yajima,M.Islets-Activating protein (IAP) in Bordetella Pertussis that potentiates Insulin Secretory Responses of Rats Journal of Biochemistry[J].1978,83:295-303.
  • 2Seino Y,Seino S,Tsrda K,Kuzuya H,Imura H.Islets-activating protein from Bordetella petussis enhancenent of pancreatic somatostatin release Horm.metab[J].Res[J].1983,15(11):563-564.
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  • 4Kikkawa R,Haneda M,Hatanakda I,Shigeta Y,Ueno T,Okuno M,Effect of islets-activating protein of Bordetella pertussis on ghucagon reolease from mice isolated islets Horm.Metab.Res[J].1981,13(12):713-714.

同被引文献14

  • 1尹一兵.用融合蛋白在大肠杆菌中高表达百日咳杆菌毒素蛋白S_3亚基基因[J].重庆医科大学学报,1996,21(2):103-106. 被引量:1
  • 2萨姆布鲁克 黄培堂译.分子克隆实验指南[M].北京:科学出版社,2002,8..
  • 3王颖.[D].乌鲁木齐:新疆农业大学,2000.
  • 4Yajima M.Islets-Activating protein (IAP) in Bordetella Pertussis that potentiates Insulin Secretory Responses of Rats[J].Journal of Biochemistry,1978,83:295-303.
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  • 6Toyota T,Kai Y,Kakizaki M,et al.Effects of islet-activating protein (IAP) on blood glucose and plasma insulin in healthy volunteers[J].Tohoku J Exp Med,1980,130(2):105-116.
  • 7Michael J C,Rogol A D.Pertusis Toxin Blocks the Somatostatin-Induced Inhibition of Growth Hormone Release and Adenosine 3,5-Monophosphate[J].Accumulation Endocrinology,1983,113(1):209-215.
  • 8Kikkawa R,Haneda M,Hatanakda I,et al.Effect of islets-activating protein of Bordetella pertussis on glucagon release from mice isolated islets[J].Horm.Metab.Res,1981,13(12):713-714.
  • 9Seino Y,Seino S,Tsrda K,et al.Islets-activating protein from Bordetella pertussis enhancenent of pancreatic somatostatin release[J].Horm.Metab Res,1983,15(11):563-564.
  • 10Fan E,Merritt EA,Verlinde CL,Hol WG.AB(5) toxins:structures and inhibitor design[J].Curr Opin Struct Biol,2000,10(6):680-685.

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