摘要
本研究利用心室纤颤引起家兔大脑急性缺血、缺氧。取脑组织行电镜观察,发现:脑神经细胞完全缺血、缺氧3min后,首先出现粗面内质网扩张,部分核蛋白体脱失和游离;接着线粒体肿胀、嵴减少或消失,严重者粗面内质网和线粒体可是空泡变;细胞核染色质溶解,核膜扩张,核膜孔扩大;细胞膜膜孔增大。暗细胞的出现是一个重要特点。作者认为.在急性完全性脑缺血、缺氧早期观察到暗细胞可分为两种,一种是神经细胞缺血、缺氧时形态学变化的表现之一;另一种是退行性变的神经细胞.在实验组和对照组均可见到。
In this rabbit experiment, we used ventricular fibrillation byelectric means leading to cerebral acute ischemia & anoxia. Biopsiedbrain tissues showed by EM complete ischemia of the brain neurons.Three minutes after anoxia, dilatation of granular endoplasmicreticulum & ribosomal detachment & isolation were seen. Followingthese, swelling of mitochondria & disapperance of the cristae occu-rred. In severe cases, there were vacuolar formations in granularendoplasmic reticulum & mitochondria. Chromatolysis, swelling &dilatation of hole of nuclear membrane, and microvacuoliztion of cellmembrane occurred. Appearance of dark neuron was the maincharacteristic. The authors considered the dark neurons, observed inacute complete cerebral ischemia & early anoxia, were of 2 types i.e. morphological changes of neuronal ischemia & anoxia, and deg-erative changes. Both of them might be seen in experimental & con-trol group.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
1989年第1期38-41,共4页
Chinese Journal of Clinical and Experimental Pathology
关键词
神经系统
脑缺血
脑缺氧
电镜
nerves system
ischemic & hypoxia
microscopy, electron
rabbit
