摘要
作者研究了不同透析膜、不同透析方法对尿毒症大、中、小分了毒物的清除情况。发现铜仿膜(CUP)做血液透析(HD)、聚砜膜(PS)作血液透析滤过(HDF)及高流量透析(HFD)对小分子物质清除均佳;TACurea均小于50mg。HD对中分子物质(MMS)有一定清除作用,对β_2m无清除效果。HDF对NlMS及β_2m清除最佳。HFD对MMS及β_2m清除较HDF及血液滤过(HF)差。HF对MMS及β_2m有良好清除效果,但对血尿素氮(BUN)及肌酐(Cr)清除较差CAPD每日清除MMS及β_2m-微球蛋白(β_2m)量不如HF、HDF及HFD,但每周清除量是HD的2～4倍,是无条件进行HF或HDF单位清除MMS及β_2m的良好方法。
In this study, authors observed and compared the clearances of different molecule weight substances between different dialysis membranes and different hemopurification methods. The results showed that the clearances of BUN by hemodialysis (HD) with cuprophan membrane, hemodiafiltration (HDF) with polysulfone and high flux dialysis (HFD) with polysulfone were all satisfactory. TACurea were all below 50 mg. Hemodialysis with cuprophan could clean out some middle molecule substances (MMS), but not β2-microglobulin (β2m). Hemodiafiltration with polysulfone had the best clearances of MMS and β2m. Hemofiltration (HF) with polysulfone had fair clearances of MMS and β2m, but the clearances of BUN and Cr by HF were not so good. The clearances of MMS and β2m by high flux dialysis were lower than those of HDF and HF. The clearances of MMS and β2m by continuous ambulatory peritoneal dialysis (CAPD) at a single time were lower than those of HF, HDF and HFD, but the general clearances of MMS and β2m by CAPD per week were two to four times higher than those by hemodialysis with cuprophan. CAPD is a choice method for those hospitals where HF or HDF can not be performed.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1993年第5期439-443,共5页
Academic Journal of Second Military Medical University
关键词
肾功能衰竭
中分子物质
血液透析
chronic renal failure
middle molecule substances
β2-microglobulin
dialysis
hemodiafiltration
hemofiltration
patients
human
