摘要
目的：评价血、尿β２微球蛋白（β２Ｍ）对早期发现前列腺增生症（ＢＰＨ）患者轻度肾功能损害的作用。方法：测定了１１２例ＢＰＨ患者的血β２Ｍ、尿β２Ｍ、血肌酐（Ｃｒ）水平、膀胱残余尿量（ＰＶＲ）及尿流率，并以６５例健康人作为对照。结果：重度梗阻组患者尿中β２Ｍ明显高于对照组（Ｐ＜０．０５），且与其膀胱残余尿量和最大尿流率（Ｑｍａｘ）有显著相关性（Ｐ＜０．０２５），而血β２Ｍ和Ｃｒ值则与对照组无明显差别（Ｐ＞０．０５）；轻度梗阻组患者血β２Ｍ、尿β２Ｍ、血Ｃｒ值与对照组无明显差别（Ｐ＞０．０５）。结论：检测β２Ｍ可早期发现ＢＰＨ患者的轻度肾功能障碍，且尿β２Ｍ较血β２Ｍ。
Objective:To evaluate the serum and urine beta2microglobulin (β2M)in early discovery of renal dysfunction in patients with benign prostatic hyperplasia(BPH)Methods:The levels of serum and unine β2M,serum creatinine (Cr),residual urine and urine flow rate were measured in 112 patients whit BPH65 normal subjects served as controlsResults:Statistical analysis revealed that urine β2M level was significantly higher in patients with flow impairment than in normal controls (P<005),and was well correlated with postvoid residuals and maximum flow rate (P<0025)Houever,there were no differences in serum β2M and Cr when comapred with the controls (P>005);The levels of serum and urime β2M,and serum Cr in patients with modest obstruction were not significantly different from those of the controls (P>005)Conclusions:The above results suggest early renal dysfunction can be discovered in patients with BPH by measuring the β2M levels and the rine β2M is more sensitive than the serum β2M and Cr
出处
《上海医学》
CAS
CSCD
北大核心
1998年第8期447-449,共3页
Shanghai Medical Journal
