摘要
为探讨不同降脂治疗方案对老年人血脂增高的疗效及预后。将 95名血脂增高离退休干部随机分成三组 :两年组用氟伐他汀隔晚 2 0mg,服用两年 ;3月组用氟伐他汀每晚 2 0mg,服用三个月 ;对照组不用降脂药 ;三组都观察两年。结果发现 ,观察三个月后 ,与对照组比较 ,两治疗组的总胆固醇和低密度脂蛋白胆固醇均较治疗前下降 ,3月组下降更明显 ,差异有显著性统计学意义 (两年组为P <0 .0 5 ,3月组为P <0 .0 1) ;观察两年后 ,两治疗组的总胆固醇和低密度脂蛋白胆固醇均较治疗前下降 ,两年组下降更明显 (两年组为P <0 .0 0 1,3月组为P <0 .0 5 ) ;对照组的总胆固醇和低密度脂蛋白胆固醇的差异无显著性 (P >0 .0 5 )。组间比较 ,观察两年后两年组 (与治疗前相比总胆固醇下降 2 3.4 % ,低密度脂蛋白胆固醇下降 2 5 % )较 3月组 (总胆固醇下降 9.5 % ,低密度脂蛋白胆固醇下降11.1% )下降明显 ,差异有显著性 (P <0 .0 5 )。两年组心血管事件发生率 (9% )明显低于对照组 (5 6 .2 % )和 3月组(31.2 % ) ,差异有显著性 (分别为P <0 .0 1和P <0 .0 5 )。结果提示 ,老年人长期服用降脂药有效安全 ,能明显减少冠心病等心血管事件的发生。
Aim To study the effect of lipid-lowing treatments on prognosis and reducing blood lipid in old people with hyperlipidemia. Methods 95 old people with hyperlipidemia were divided into three groups randomly.All patients received low fat diet. Patients of group 1 were treated with Fluvastatin 20 mg alternation night for two years. Group 2 were treated with Fluvastatin 20 mg every night for three month. No lipid lowing drug was received in group 3(control group). Investigation was followed up for two years. Results Plasma lipids level of the patients in the group 1 (TC 5.7±1.3 mmol/L,LDL 3.2±0.7 mmol/L)and group 2 (TC 5.5±0.9 mmol/L,LDL 3.0±0.7 mmol/L)was significantly lower at the 3rd month than that before treatment (P<0.05,P<0.01). Two years later,the plasma lipid were markedly decreased in group 1(TC 4.9±1.2 mmol/L,LDL 2.7±0.9 mmol/L,P<0.001),however,that of group 2(TC 5.7±1.0 mmol/L、LDL 3.2±0.7 mmol/L)increased again,the difference between these two groups was significant(P<0.05). Plasma lipids level of the patients in the control group (TC 6.5±1.1 mmol/L, LDL3.7±0.8 mmol/L)was the same in two years than that before treatment(P>0.05).Compared with group 2,plasma lipids level of the patients in group 1significantly decreased two years later(P<0.05). The incidence of cardiovascular events of group 1 (9%)was lower than group 3 (56.2%,P<0.01) and group 2 (31.2%,P<0.05). Conclusion It was safe and effective to take low-dose lipid-lowing drug of Fluvastatin for a long time. The incidence of cardiovascular events and coronary heart disease was decreased.
出处
《中国动脉硬化杂志》
CAS
CSCD
2004年第2期212-214,共3页
Chinese Journal of Arteriosclerosis
