摘要
目的比较舒芬太尼与瑞芬太尼静脉麻醉的临床效果,为今后的临床实践提供数据支持。方法选取外科手术的患者91例,随机分为2组,即舒芬太尼组(A组)和瑞芬太尼组(B组)进行临床麻醉。在各不同时间点监测患者的血液动力学指标、儿茶酚胺浓度以及术后苏醒情况,并进行对比观察。结果 2组患者在气管插管前(T1)时,各组收缩压(systolic pressure,SP)、舒张压(diastolic pressure,DP)、心率(heart rate,HR)水平比诱导麻醉前(T0)均有显著下降(P<0.05),到气管插管后1min(T2)时,SP、DP、HR水平比T1有显著上升(P<0.05),并显著超过了T0的水平(P<0.05),且A组比B组上升的幅度更大(P<0.05)。肾上腺素和去甲肾上腺素在T2和手术结束后30min(T6)时,A组水平均比T0有显著提升(P<0.05)。B组患者自主呼吸恢复时间(5.2±1.9)min,睁眼时间(7.2±2.0)min以及意识清醒时间(14.6±2.3)min均少于A组(t=14.382,14.934,12.601,P<0.01),差异具有统计学意义。2组均未发生不良反应。结论瑞芬太尼组具有良好的麻醉效果,术后患者苏醒快,自我呼吸早。术中血液动力学指标及儿茶酚胺指标变化较为平稳,有利于机体内环境平衡。
Objective To compare the clinical intravenous anesthesia effect of sufentanil and remifentanil respectively, in order to provide data support for future clinical practice. Methods 91 surgery patients from February 2013 to October 2013 were selected and randomly divided into 2 groups, the one is sufentanil group (group A), and the other is remifentanil group(group B). The change of hemodynamic indexes, catecholamine concentration and woke up time after surgery in two groups were monitored and compared. Results Compared with T 0, levels of SP, DP, HR in two groups were signiifcantly lower (P<0.05), at the moment of T 2, the levels of SP, DP, HR level got signiifcantly higher(P<0.05), even surpass T 0(P<0.05). And the range of the rise in group A was signiifcant than that in group B(P<0.05).Epinephrine and norepinephrine of group A in T 2 and T 6, were higher than T 0 (P<0.05). The spontaneous breathing recovery time was, (5.2±1.9)min, open eyes’time, (7.2±2.0) min, and conscious time was(14.6±2.3)min in group B, which were lower than that of group A(t=14.382, 14.934, 14.382, P<0.01).There were no adverse reactions in both groups. Conclusion Remifentanil has good anesthetic effect, postoperative patients wake up soon, self breathing early. The change of hemodynamic index and catecholamine index are stable and beneifcial to internal environment balance.
出处
《中国生化药物杂志》
CAS
北大核心
2014年第2期81-83,共3页
Chinese Journal of Biochemical Pharmaceutics
基金
湖北省自然科学基金(2012FFC060)
关键词
舒芬太尼
瑞芬太尼
麻醉效果
sufentanil
remifentanil
anesthesia effect
