摘要
观察10例智力低下儿童及10例智力正常儿童外周血淋巴细胞染色体畸变半及脆性部位。结果表明,智力低下儿童染色体畸变半及脆性部位表达率均明显高于正常对照组。尤其是脆性部位3p14、7q32、4q31、1q32、10q22、14q23等表达频率明显增加。
Peripheral blood lymphocytes chromosome aderration (CBR) and fragila site rates (FR) from 10 cases of mentally retarded children and 10 mentally normal controls were observed.The results showed the CAR and FR of mentally retarded children were significantly higher than those of the controls.The more frequent sites in patients were CFS at 3 P14,7q32,4q31,1P32,10q22,14q23 etc.
关键词
染色体畸变率
脆性部位
智力迟钝
mantally retardation
chromosome aberration
fragile site
