摘要
目的 :确定脑室注射UrocortinⅢ后被激活细胞群的分布 ,并判断这些细胞群的分布与其受体 (促肾上腺皮质激素释放因子 2型受体 ,CRF2R)的分布吻合程度 .方法 :应用免疫组织化学方法观察侧脑室注射UrocortinⅢ对大鼠不同脑区Fos表达的影响 .结果 :脑室给予UrocortinⅢ引起许多脑区Fos表达明显增多 ,包括隔外侧核、终纹床核、下丘脑室旁核、弓状核、杏仁中央核、臂旁核、孤束核和最后区 .结论 :侧脑室给予UrocortinⅢ激活了与味觉和摄食调控相关的细胞群以及与应激相关的细胞群 。
AIM: To identify cell groups responsive to central urocortin Ⅲ administration and to evaluate the extent to which these cell groups may conform to the sites of CRF2R (corticotropin releasing factor 2 receptor ) expression. METHODS: The influence of intracerebroventricular injection of urocortin Ⅲ on Fos expression in rat brain areas was observed with immunohistochemical staining technique. RESULTS: Urocortin Ⅲ induced Fos expression in several brain areas, including lateral septal nucleus (LS), the bed nucleus of the stria terminalis (BST), paraventricular hypothalamus nucleus (PVN), arcuate hypothalamic nucleus (ARC), the central nucleus of the amygdala (CeA), parabrachial nucleus (PBN), nucleus of the solitary tract(NTS) and area postrema (AP). CONCLUSION: Intracerebroventricular injection of urocortin Ⅲ activates cell groups related with gustation, feeding and stress, the distribution of which partially overlaps with the sites of CRF2R expression.
出处
《第四军医大学学报》
CAS
北大核心
2004年第11期969-972,共4页
Journal of the Fourth Military Medical University
基金
国家自然科学基金 (30 2 70 4 54)
陕西省科技发展计划项目(2 0 0 2K1 0 G7 0 1 )
