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CRF肽家族新成员——Ucn2、Ucn3与焦虑样行为

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摘要 本文就Ucn2和Ucn3对焦虑样行为的调节研究进展作一综述。
作者 宋飞 王旭梅
机构地区 中国医科大学第二临床医院心理科
出处 《国际精神病学杂志》 2007年第1期29-32,共4页 Journal Of International Psychiatry
关键词 Ucn2 Ucn3 焦虑样行为
分类号 R749.7-2 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献15

  • 1Bale TL, Picetti R, Contarino A, et al. Mice deficient for both corticotropin-raleasing factor receptor 1 ( CRFR1 ) and CRFR2 have an impaired stress response and display sexually dichotomous anxiety-like behavior. J Neuroscience, 2002; 22 (1): 193-199.
  • 2Pellymounter MA, Joppa M, Ling N, et al. Behavioral and neuroendoerine effects of the selective CRF2 receptor agonist Urocortin Ⅱ and Urocortin Ⅲ. Peptides, 2004; 25 (4): 659-666.
  • 3Venihald M, Sakihara S, Subramanian S, et al. Urocoain Ⅲ, a brain neuropeptide of the corficotropin-releasing factor: modulation by stress and attenuation of some anxiety-like behavior. J Neuroendocfinol. 2004; 16 (5): 411-422.
  • 4Hsu SY, Hsueh AJ. Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor. Nat Med. 2001; 7 (5): 605-611.
  • 5Valdez GR, Inoue K, Koob GF, et al. Human urocortin Ⅱ : mild locomotor suppressive and delayed anxiolytic-like effects of a novel corticotropin releasing factor related peptide. Brain Research, 2002; 943: 142-150.
  • 6Valdez GB, Zorrilla EP, River J, et al. Locomotor suppressive and anxiolytic-like effects of urocortin 3, a highly selective type 2 corticotropin-releasing factor agonist. Brain Res. 2003; 980 (2) : 206-212.
  • 7Ohata H, Shibasaki T. Effect of urocortin 2 and 3 on motor activity and food intake in rats. Peptides, 2004, 25 (10): 1703-1709.
  • 8De Groote L, Penalva RG, Flachskamm C, et al. Differential monoaminergic, neuroendocrine and behavioural responses after central administration of cortieotropin-releasing factor receptor type 1 and type 2 agonists. J Neurochem. 2005; 94 (1) : 45- 56.
  • 9Staub DR, Spiga F, Lowry CA. Urocortin 2 increases c-fos expression in topographically organized subpopulations of serotonergic neurons in the rat dorsal raphe nucleus. Brain Rest. 2005; 1044 (2) : 176-189.
  • 10Amat J, Tamblyn JP, Paul ED. Microinjection of urocortin 2 into the dorsal raphe nucleus activates serotonergic neurons and increases extracellular serotonin in the basolateral amygdala.Neuroscienee, 2004; 129: 509-519.

二级参考文献10

  • 1Lewis K, Li C, Perrin MH, et al. Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor [J]. Proc Natl Acad Sci USA, 2001; 98(13): 7570-7575.
  • 2Wchenko PE, Vale WW. Urocortin III-immunoreactive projections in rat brain: Partial overlap with sites of type 2 corticotrophin-releasing factor receptor expression[J]. J Neurosci, 2002; 22(3): 991-1001.
  • 3Li C, Chen P, Vaughan J, et al. UrocortinIII is expressed in pancreatic beta-cells and stimulates insulin and glucagons secretion [J]. Endocrinology, 2003; 144(7): 3216-3224.
  • 4Brar BK, Jonassen AK, Egorina EM, et al. Urocortin-II and urocortin-III are cardioprotective against ischemia reperfusion injury: An essential endogenous cardioprotective role for corticotropin releasing factor receptor type 2 in the murine heart[J]. Endocrinology, 2004;145(1):24-35.
  • 5Martinez V, Wang L, Rivier JE, et al. Differential actions of peripheral corticotropin-releasing factor (CRF), urocortin II, and urocortin III on gastric emptying and colonic transit in mice: Role of CRF receptor subtypes 1 and 2[J]. J Pharmacol Exp Ther, 2002; 301(2): 611-617.
  • 6Valdez GR, Zorrilla EP, Rivier J, et al. Locomotor suppressive and anxiolytic-like effects of urocortin 3, a highly selective type 2 corticotropin-releasing factor agonist[J]. Brain Res, 2003; 980(2): 206-212.
  • 7Million M, Maillot C, Saunders P, et al. Human urocortin II, a new CRF-related peptide, displays selective CRF (2)-mediated action on gastric transit in rats [J]. Am J Physiol Gastrointest Liver Physiol, 2002; 282(1): G34-G40.
  • 8Cullen MJ, Ling N, Foster AC, et al. Urocortin, corticotropin-releasing factor -2 receptors and energy balance [J]. Endocrinology, 2001; 142(3):992-999.
  • 9Million M, Saunders P, Rivier J, et al. Compound 338-86-15, a novel peptide CRF-R2 antagonist, selectively blocks CRF and stress-induced delayed gastric emptying in rats. [J]. Soc Neurosci Abstr, 2001; 27: 817-839.
  • 10Reul JM, Holsboer F. Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression [J]. Curr Opin Pharmacol, 2002; 2(1): 23-33.

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国际精神病学杂志
2007年 第1期

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