摘要
目的 探讨新生儿窒息时一氧化氮 (Nitrogenmonoxide ,NO)、一氧化氮合成酶 (Nitrogenmonoxidesyntase ,NOS)水平的变化及其对判断预后的指导意义。方法 采用比色等方法测定 32例窒息新生儿及 30例正常新生儿血浆一氧化氮、一氧化氮合成酶活性水平。结果 正常对照组NO、NOS水平分别为 (72 .84± 1 2 .35) μmol/L和 (0 .2 0 3± 0 .0 5)U/mg ,窒息组为 (1 2 9.80± 32 .66) μmol/L和(0 .352± 0 .1 2 4 )U/mg ;其中轻度窒息组为 (1 0 5 .65± 36 .30 ) μmol/L和 (0 .2 89± 0 .0 9)U/mg ;重度窒息组为 (1 4 4 .55± 2 6 .32 ) μmol/L和 (0 .364± 0 .0 1 0 )U/mg。窒息新生儿NO、NOS水平较正常新生儿明显升高 (P <0 .0 1 ) ,重度窒息患儿较轻度窒息患儿升高 (P <0 .0 1 )。结论 NO、NOS水平高低与窒息新生儿脑损伤程度和预后有关 ,可作为判断新生儿窒息及其所致新生儿缺氧缺血性脑病(HIE)
Objective To investigate the levels of nitric oxide(NO) and nitric oxide synthase(NOS) in asphyxia neonatorum and its significance on prognosis judgments. Methods Levels of nitric oxide and nitric oxide synthase were measured by color matching method in 32 asphyxia neonatorums as well as 30 normal neonates. Results NO and NOS levels of the control groups were (72.84±12.35) μmol/L and (0.203±0.05)U/mg respectively,and those of the asphyxia groups were ( 129.80 ±32.66)μmol/L and (0.352±0.124)U/mg.NO and NOS levels of mild asphyxia group were (105.65±36.30)μmol/L and (0.289±0.09)U/mg,those of severe asphyxia group were (144.55±26.32)μmol/L and (0.364±0.01)U/mg respectively.No and NOS levels in asphyxia group were significantly higher than those in normal neonates(P<0.01),and those in severe asphyxia group were significantly higher than those in mild asphyxia group(P<0.01). Conclusion NO and NOS levels have relationship with the cerebral damage degree as well as the prognosis,which can be used as one of the restoration and prognosis level indications.
出处
《中国煤炭工业医学杂志》
2004年第6期492-493,共2页
Chinese Journal of Coal Industry Medicine
关键词
窒息新生儿
NO
NOS
预后
血浆
asphyxia
nitric oxide
nitric oxide synthase
neonatorum
