摘要
目的:观察经瑞舒伐他汀(可定10mg)治疗4周后,不同类型冠心病患者LDL-C的变化情况以及CX3CR1在不同类型冠心病患者外周血单核细胞中的表达。方法:选择经冠状动脉造影后确诊为冠心病的患者,其中40例稳定型心绞痛病例,40例不稳定型心绞痛病例及40例急性ST段抬高型心肌梗死的病例作为研究对象:以冠状动脉造影正常的40例患者作为正常对照组。采用均相酶显色法检测LDL-C水平,利用流式细胞仪直接免疫荧光法检测不同类型患者外周血单核细胞上CX3CR1的表达。结果:经过4周的瑞舒伐他汀治疗后正常对照组及各类型冠心病患者血脂水平较治疗前均有所下降(P<0.01),CX3CR1在各组患者外周血单核细胞中的表达较治疗前均减低(P<001)。结论:瑞舒伐他汀可有效降低血脂,同时具有抗炎作用。
Objective:To observe the effect of rosuvastatin on change of LDL-C and CX3CR1 expression on monocytes in indifferent types of patients with coronary heart disease(CHD) after 4 weeks.Methods:LDL-C were measured by the colorimetric method and the expression of CX3CR1 on monocytes were measured by direct immunofluorescence techniques associated with flow cytometer(FCM) in 40 patients with stable angina pectoris(SAP) confimed by coronary arteriography,40 patients with unstable angina pectoris,40 patients with acute STsegment elevation myocardial infarction,40 patients with nomal individuals as the control.Results:Compared with the data before treatment,rosuvastatin decreased the level of LDL-C and the expression of CX3CR1 at the 4th weak from both the control and CHD groups,and the differences were statistically significant(P < 0.01).Conclusion:Rosuvastatin can significantly decrease serum lipid level and have an anti-inflammatory effect.
出处
《广州医学院学报》
2014年第2期8-10,共3页
Academic Journal of Guangzhou Medical College
