摘要
用固体超强酸SO2-4/Fe2O3催化N,N 二乙氨基乙醇与9个含芳香环羧酸的酯化反应,合成了9个相应的酯,产率在75%～95.6%之间.讨论了不同的固体超强酸及催化剂用量,溶剂和反应温度,反应时间等因素对酯化产率的影响.实验结果表明:当催化剂用量占反应物总量的3.4%～3.8%,溶剂为二甲苯,反应温度140℃,反应时间6h的条件下,酯化产率最高.
N,N-Dialkylaminoethyl esters have been found to possess a range of interesting biological activities. Reported methods in the literature have one or more drawbacks such as the use of harsh reaction conditions and environmental unfriendly reagents required more than one reaction steps and, in some cases, giving low yields of the products. Therefore more efficient methods for the preparation of this type of compounds remain to be developed. In this paper we report an environmentally friend and efficient one step synthesis of N, N-diethylaminoethyl esters. Under optimized conditions, nine N, N -diethylaminoethyl aromatic esters have been synthesized using solid superacid Fe_2O_3/SO^(2-)_4 as catalyst with yields ranging from 75% to 95.6%. Factors which affect the esterification such as types of solid superacids, solvents, reaction temperature, reaction time and amounts of catalyst were studied.This method has advantages over the traditional ones in that: it requires only catalytic amount of catalyst and the work-up procedure is simple; it does not form amine salt as protonic acid condensation agents do; it produces no acidic waste and is less corrosive to the reaction vessels than other conventional condensation agents. This method is expected to have potenteal application in the preparation of other diethylaminoethyl esters and in general ester synthesis.
出处
《厦门大学学报（自然科学版）》
CAS
CSCD
北大核心
2004年第4期507-512,共6页
Journal of Xiamen University：Natural Science
