摘要
目的观察普伐他汀对急性缺血性卒中病人血脂、血液流变学的影响。方法138例急性期脑卒中病人随机分为常规治疗组(n=69)和普伐他汀治疗组(n=69),普伐他汀治疗组除进行常规治疗外,加用普伐他汀20 mg/d,分别于入院及临床治疗15 d检测患者的血脂、血液流变学指标,比较治疗前后疗效与血脂、血液流变学指标的变化。结果普伐他汀组的疗效优于常规治疗组(P<0.05);增加普伐他汀治疗后,低切变率下全血黏度、高切变率下全血黏度、血浆黏度、血小板聚集率、纤维蛋白原、总胆固醇(TC)明显下降(P<0.01),低密度脂蛋白胆固醇(LDL-C)虽有下降趋势,但未见有统计学意义(P>0.05)。甘油三酯(TG)、高密度脂蛋白(HDL-C)变化不确定(P>0.05)。用药期间未见普伐他汀严重不良反应。结论急性期脑卒中患者早期服用普伐他汀可降低血中TC与LDL-C,起到改善血液流变学作用;但对TG和HDL-C影响较小。
Objective To explore effects of Pravastatine on blood lipid and hemorheology of patients with acute ischemic cerebral stoke.Methods 138 patients with acute ischemic cerebral stoke were divided into the Pravastatine group(Pravastatine tablet 20 mg/d,n=69) and the conventional treatment group(n=69).Blood lipid and hemorheology indicator of the patients were recorded and compared to those before the treatment for 15 days.Results It showed that curative effect in the Pravastatine group was better than that in the conventional treatment group(P<0.05).Given Pravastatine,whole blood viscosity under low shear rate,whole blood viscosity,Plasma viscosity,platelet aggregation rate,fibrinogen,TC,under high shear rate all decreased significantly(P<0.01),low density lipoprotein cholesterol(LDL-C) tended to decrease,but showed no statistical significance(P>0.05),and there wasn′t certain change in triglycerides(TG),high-density lipoprotein cholesterol(HDL-C)(P>0.05),Pravastatine had no serious adverse reaction during the treatment.Conclusion Pravastatin could reduce TC and LDL to improve hemorheology of patients with acute ischemic cerebral stoke in early stage,but had less effect on TG and HDL-C.
出处
《吉林医药学院学报》
2010年第2期68-71,共4页
Journal of Jilin Medical University
关键词
普伐他汀
急性脑卒中
血液流变学
血脂
pravastatine
acute ischemic cerebral stoke
hemorheolog
blood lipid
