期刊文献+

欧洲神经病学协会联盟的成人癫持续状态管理指南 被引量:4

EFNS guideline on the management of status epilepticus in adults
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摘要 本文目的旨在评估文献及探讨针对成人癫持续状态(SE)各种治疗策略的证据等级。我们对1966年~2005年1月间MEDLINE和EMBASE上发表的相关文献及2005年1月~2009年1月间最新版本的所有相关出版物进行检索。此外,还对Cochrane临床对照试验注册中心(CENTRAL)进行检索。推荐就是基于这些文献以及我们对主题词相关参考文献的判断并通过建立共识的方式获得。若缺乏证据但共识明确,我们提出良好实践指导。全面性惊厥性癫持续状态(GCSE)的推荐治疗路径为直接予以4~8 mg劳拉西泮或10 mg地西泮,继以18 mg/kg苯妥英静脉注射。如首次给药后癫发作仍持续10 min以上,建议再次予以4 mg劳拉西泮或10 mg地西泮静脉注射。难治性GCSE需要麻醉剂量的巴比妥、咪唑安定或异丙酚治疗,药物剂量需以脑电图发放被抑制来滴定至少24 h。非惊厥性SE的初始治疗取决于其发作类型和病因。复杂部分性SE的初始治疗同GCSE,若难治则予以左乙拉西坦、苯巴比妥或丙戊酸等非麻醉类药物。对于不明显的SE(subtle SE),大多需要静脉注射麻醉药。
出处 《神经病学与神经康复学杂志》 2011年第4期190-193,共4页 Journal of Neurology and Neurorehabilitation
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  • 1胡剑平,白栓成,秦广平.咪唑安定治疗癫痫持续状态的体会[J].内蒙古医学杂志,2004,36(9):713-713. 被引量:2
  • 2王治静,陈小聪,李华.咪达唑仑治疗小儿癫痫持续状态30例疗效观察[J].陕西医学杂志,2005,34(1):117-118. 被引量:6
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  • 7Rossetti AO,Urbano LA, Delodder F, et al. Prognostic valueof continuous EEG monitoring during therapeutic hypothermiaafter cardiac arrest[J]. Crit Care,2010,14 : 173.
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  • 9Marchi N, Tierney W,Alexopoulos AV,et al. The etiologicalrole of blood-brain barrier dysfunction in seizure disorders[J].Cardiovasc Psychiatr Neurol,2011,9(4) :652-655.
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