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双端氨基聚乙二醇的合成 被引量：5

Synthesis of amino polyethylene glycol
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摘要 聚乙二醇(PEG)与对甲苯磺酰氯(TsCl)进行酯化反应,制备出聚乙二醇对甲苯磺酸酯PEG-Ors(1)收率65%。在高压釜中,PEG-OTS与氨水进行氨基化反应制备出双端氨基聚乙二醇Amino-PEG(2),收率70%,并一步研究了"酯化"和"氨基化"的合成原理。中间体PEG-OTs及产品Amino-PEG的结构经氢核磁共振谱(1H NMR)表征。 Polyethylene glycol tosylate PEG—OTs 1 was synthesized by polyethylene glycol(PEG) and p-toluenesulfonyl chloride(TsCl).The esterification reaction yield was 65%.Amino polyethylene glycol(Amino-PEG 2) was prepared by PEG-OTs and ammonia water in autoclave.The amination reaction yield was 70%.The esterification and amination synthesis mechanism were studied.PEG-OTs and Amino-PEG was charactered by 1H-nuclear magnetic resonance 1H NMR.
作者 于宏伟 郧海丽 高岩磊 王惠 王娟敏
机构地区 石家庄学院化工学院 同辉电子科技股份有限公司
出处 《化工中间体》 2011年第9期49-51,共3页
关键词 聚乙二醇 对甲苯磺酰氯 酯化 氨基化 合成 polyethylene glycol p-toluenesulfonyl chloride esterification amination synthesis
分类号 TQ31 [化学工程—高聚物工业]
  • 相关文献

参考文献12

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共引文献90

同被引文献58

  • 1李先红,崔萍,刘榛榛.双端羧基聚乙二醇的合成[J].化学与生物工程,2005,22(10):42-43. 被引量：10
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引证文献5

二级引证文献9

化工中间体
2011年 第9期

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