摘要
目的:观察重组人表皮生长因子(rhEGF)治疗烧伤的疗效和安全性。方法:以rhEGF治疗各类烧伤302例(男性213例,女性89例,年龄33±11),其中双盲自身对照190例,开放组112例,在常规治疗(1%磺胺嘧啶银霜)基础上,局部喷涂rhEGF或安慰剂。结果:rhEGF用于浅Ⅱ°、深Ⅱ°、供皮区、残余创面,试验组较对照组愈合时间分别提前2,3,3,6d,不良反应轻微。结论:rhEGF对烧伤创面具有明显的促进愈合的作用。
Objective: To observe the efficacy and safety of recombinant human epidermal growth factor (rhEGF)in the treatment of burn wounds. Methods: Three hundred and two patients (M213, F89;age 33±11) were treated with rhEGF,including 190 in double auto-control trials and 112 in open trials, rhEGF or placebo were topically used on the wounds respectively on the base of routine treatment (1% sulfadiazine silver cream). Results: The healing time of superficial Ⅱ°, deep Ⅱ° donor areas and granulation wounds was 2,3,3,6d shorter respectively in trial group than in control group and the adverse reactions were mild. Conclusion: rhEGF can promote the healing of burn wounds.
出处
《感染．炎症．修复》
2000年第1期56-58,共3页
Infection Inflammation Repair
关键词
重组人表皮生长因子
烧伤治疗
Ⅱ期临床试验
Recombinant human epidermal growth factor Treatment of burns Phase Ⅱ clinical trial
