摘要
目的 研究三氧化二砷(As2O3)对原发性肝癌的治疗价值。 方法 对22例原发性肝癌病人采用全身静滴、TACE后经股动脉肝动脉埋置皮下化疗泵连续区域灌注化疗。结果 均给予2个周期,5例肿瘤体积缩小50%以上,无新病灶出现,11例无变化,6例进展。20例食欲改善,15例体重增加。14例AFP下降或降至正常。10例伴有肝区疼痛或不适减轻或消失。10例发热(37.5～38.5℃),2例出现药疹,停药后消失。21例出现双下肢浮肿,颜面部轻度浮肿、腹胀和纳差。结论 应用三氧化二砷连续全身或经肝动脉区域灌注化疗对原发性肝癌具有一定的治疗价值,毒副反应轻,疗效确切。
Objective To investigate the value of arsenic trioxide(As2O3) in the treatment ofprimary hepatic carcinoma(PHC). Methods Twenty-two patients with PHC underwent vein drip or post-operative or post-TACE(Transcatheter Arterial Chemotherapy Embolization). An implantable injectingcatheter and port system were embedded in left, right or proper hepatic artery of each patient, accordingto the position of the tumor. Results After the treatment of 2 courses, the tumor size decreased forover 50% in 5 patients without new tumors detected. The tumor size remained unchanged in 11 patients andprogressed in the 6 patients. Spirit was improved in 8 patients and body weight increased in 15. AFP valuedecreased in 14 patients and pain in hepatic area disappeared in 10. Fever occurred in 10 patients andpharmaco papule in 2. Both lower limb and face edema, meteorism and anorexia were observed in 21 patients.Conclusions Arsenic trioxide is an efficient chemical with low toxicity and the best method for itsadministration is continuous regional infusion through the vein and the hepatic artery.
出处
《国际医药卫生导报》
2003年第22期7-8,共2页
International Medicine and Health Guidance News
关键词
肝肿瘤
三氧化二砷
化疗
Hepatic neoplasm Arsenic trioxide Chemotherapy
