摘要
研究了以对氯苯甲醛(PCAD)和无水KF为原料合成对氟苯甲醛(PFAD)的氟化反应。在溶剂选择、催化机理、工艺优化、动力学以及副反应研究等方面进行了相关探讨。在以硝基苯为溶剂,n(KF)∶n(PCAD)∶n(Ph4PBr)∶n(催化剂A)=3∶1∶0.1∶0.05、反应温度210℃、反应时间8 h的最佳工艺条件下,产品对氟苯甲醛的收率可达80.9%,纯度99.5%以上。
The fluorination of 4-chlorobenzaldehyde was studied in solvents using spray-dried KF as fluorinating agent.In addition,the factors influencing the yield were discussed on solvents selecting,catalytic mechanism,process optimizing,dynamical equation and by-reaction control.Under the optimum reaction conditions as n(KF)∶n(PCAD)∶n(Ph_4PBr)∶n(Cat.A)=3∶1∶0.1∶0.05,reacting at 210℃ for 8 h with nitrobenzene as a solvent,the yield of 4-fluorobenzaldehyde can reach 80.9% with purity of higher than 99.5%.
出处
《现代化工》
CAS
CSCD
北大核心
2006年第z1期209-212,共4页
Modern Chemical Industry
基金
江苏省科技攻关项目(BE2004045)
关键词
对氯苯甲醛
对氟苯甲醛
卤素交换氟化
相转移催化
防脱卤剂
4-chlorobenzaldehyde
4-fluorobenzaldehyde
halogen-exchange fluorination
phase transfer catalysis
anti-dehalogenating agent
