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内皮素对心脏功能的影响 被引量：1

Influence of Endothelin on the Function of Heart
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摘要 内皮素 (Endothelin ,ET)是由血管内皮细胞产生的具有强烈缩血管作用的血管活性肽 .大量实验表明 ,内皮素对心脏具有广泛的影响 ,使冠状血管收缩 ,对心脏产生正性肌力作用 。 Endothelin is a potent vasoconstrictor peptide produced by vascular endothelial cells.A lot of experimental evidences revealed that ET had wide effects on heart.It produces coronary vasoconstriction and exerts postive inotropic effect on heart.By specific endothelin receptors it also plays a role in the modulation of the neurohumoral factors acting on the cardiomyocytes.
作者 康炜东 白旭华 腾河 王丽梅
机构地区 内蒙古民族大学临床医学院 内蒙古通辽市医院
出处 《内蒙古民族大学学报（自然科学版）》 2002年第5期446-447,共2页 Journal of Inner Mongolia Minzu University：Natural Sciences
关键词 内皮素 内皮素受体 心脏 Endothelin Endothelin receptors Heart
分类号 R711.75 [医药卫生—妇产科学]
  • 相关文献

参考文献15

  • 1[1]Rikako Y-K, Takashi M, Tomoko H, et al. Role of Endothelin in Deterioration of Heart Failure Due to Cardiomyopathy in Hamsters[J]. Circulation, 1999,99:2171-2176.
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  • 3[3]Darrell L L,Joseph R H,Carmen H-L. Endothelin Enhances and Inhibits Adrenal Catecholamine Releace in Deoxycorticosterone Acetate-Salt Hypertensive Rats[J]. Hypertension, 2000,35[part 2]:385-390.
  • 4[4]Giovan G M,Anthony E,Anna R R,et al. Comparison of the cardiovascular and neural activity of endothelin-1, -2,- 3 and respective proendothelins: effects of phosphoramidon and thiorphan[J]. Br J Pharmacol, 1993,110:331-337.
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  • 6[6]Timothy D W,Graham H A,Roger C,et al. Use of the endothelin antagonists BQ-123 and PD 142893 to reveal three endothelin receptors mediating smooth muscle contraction and the release of EDRF[J]. Br J Pharmacol, 1993,110,777-782.
  • 7[7]Peter J H. Endothelin-1(ET-1)-induced contraction in rat isolated trachea:involvment of ETA and ETB receptors and multiple signal t rarsduction systems[J]. Br J Pharmacol, 1993,110: 435-411.
  • 8[8]Patricia J M, Charles J M, David H, et al. Chronic Endothelin Receptor Antagonism Preserves Coronary Endothelial Function in Experimental Hypercholesterolemia[J]. Circulation, 1999,99: 1802-1809.
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二级参考文献3

  • 1Li K，Circ Res，1991年，69卷，301页
  • 2An R H，中国药理学报，1990年，11卷，310页
  • 3何瑞荣，心血管生理学，1987年，75页

共引文献6

同被引文献14

  • 1[1]Wada A, Ohnishi M, et al. Chronic effects of an endothelin-converting enzyme inhibitor on cardiorenal and hormonal function in heart failure. Clinical science, 2002,103(48):25 4S-257S.
  • 2[2]Xinwen Wang, Masato Ohnishi,Atsuyuki Wada, et al. Endothelin-1 promotes vascular structural remodeling during the progression of heart failure:Prevention of vascular remodeling using a specific endothelinconverting enzyme inhibitor. Life sciences, 2001,69(21):2477-2488.
  • 3[3]Tadano K, Suzuki Jet al. Pathophysiological roles of endogenous endothelin-1 in dogs with chronic heart failure produced by rapid right ventricular pacing. Pharmacol Exp Tber, 2001;298(2):729-736.
  • 4[4]Armour, J.A. Comparative Effects of Endothelin and Neurotensin on Intrinsic Cardiac Neurons In Situ.Peptides, 1996,17(6):1047-1052.
  • 5[5]Jocelyn Dupuis, Gordon W. Moe, et al. Reduced pulmonary metabolism of endothe -lin-1 in canine tachycardiainduced heart failure. Cardiovascular Research, 1998,39:609-616.
  • 6[6]Stephan-Gueldner Markus, Inomata Akira. Coronary arterial lesions induced by endothelin antagonists. Toxicology Letters, 2000,112-113:531-535.
  • 7[7]Endoh, Masao. The Effects of Various Drugs on the Myocardial Inotropic Response. General Pharmacology,1995,26(1):1-33.
  • 8[8]Chu L, Takahashi R, et al. Signal transduction and Ca2+signaling in contractile regulation induced by crosstalk between endothelin-1 and norepinephrine in dog ventricular myocardium. Circ Res, 2003,92(9):1024-1032.
  • 9[9]Becker Ruediger, Merkely Be la, et al. Ventricular arrhythmias induced by endothelin-1 or by acute ischemia:a comparative analysis using three-dimensional mapping. Cardiovascular Research, 2000,45(2):310-320.
  • 10[10]Alberola Aguilar,Antonio M, et al. Intravenous BQ-123 and phosphoramidon reduce ventricular ectopic beats and myocardial infarct size in dogs submitted to coronary occlusion and reperfusion General Pharmacology, 2000,35(3):143-147.

引证文献1

内蒙古民族大学学报（自然科学版）
2002年 第5期

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