内皮素系统在犬心力衰竭中作用的研究进展
Review on Endothelin in Canine Heart Failure
摘要
内皮素(ET)不仅能够收缩血管,而且能够促进细胞生长与分裂。ET受体属于G蛋白偶联家族。在生理病理情况下ET与其受体结合后产生一系列的信号传递,从而导致犬多种心血管疾病,例如心力衰竭(HF)和冠状动脉疾病等。在HF的实验研究和初步临床实践中使用ET受体拮抗剂治疗HF已取得了显著的效果,ET受体拮抗剂改善了血液动力学,增加了心脏指数,抑制了心肌重构和心室肥大,同时延长了存活时间。
出处
《广东畜牧兽医科技》
2004年第2期22-25,共4页
Guangdong Journal of Animal and Veterinary Science
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