摘要
目的探讨血清中CA125水平在盆腔肿物的鉴别诊断中的临床价值。方法采用电化学发光法测定160例患者的血清CA125水平,共分为4组:良性病变(不包括卵巢巧克力囊肿)、炎性病变、卵巢巧克力囊肿和上皮性卵巢恶性肿瘤。结果良性病变组:(35.64±72.32)u/mL,95%CI为12.51-58.77u/mL;炎性病变组:(70.15±72.92)u/mL,95%CI为46.83-93.48u/mL;卵巢巧克力囊肿组:(113.89±128.17)u/mL,95%CI为72.90-154.88u/mL;上皮性卵巢恶性肿瘤组:(820.92±1053.28)u/mL,95%CI为484.06-1157.78u/mL。其中良性病变组与巧克力囊肿组、上皮性卵巢恶性肿瘤组间CA125水平差异有统计学意义,P<0.05,但与炎性病变组间差异无统计学意义,P>0.05;炎性病变组与上皮性卵巢恶性肿瘤组间CA125水平差异有统计学意义,P<0.05,但与巧克力囊肿组间差异无统计学意义,P>0.05;巧克力囊肿组与上皮性卵巢恶性肿瘤组间CA125水平差异有统计学意义,P<0.05。结论说明血清CA125测定对鉴别卵巢肿物良恶性的价值很明确,但特异性较差,通过提高界值来改善其特异度,如果CA125高于400u/mL,高度怀疑卵巢癌,但对于良性病变/炎性病变、巧克力囊肿/炎性病变的鉴别意义不大,依据CA125水平可以大致推测肿物性质,对治疗有一定帮助,但实践中应注意结合临床特点及其他检查具体分析,避免误诊误治。
[Objective] To investigate the effect of CA125 in the differentiatial diagnosis of ovarian mass.[Methods] Electro-chem-iluminescence method was used to detect serum CA125 of 160 cases,which were divided into 4 groups,each including 40 cases:benign leision(except for ovarian endometriosis cyst);inflammatory leision;ovarian endometriosis cyst;epithelial ovarian carcinoma.[Result] ① Benign leision(except for ovarian endometriosis cyst):(35.64±72.32)u/mL,95%CI 12.51～58.77u/mL;② inflammatory leision:(70.15±72.92)u/mL,95%CI 46.83～93.48 u/mL;③ ovarian endometriosis cyst:(113.89±128.17)u/mL,95%CI 72.90～154.88 u/mL;④ epithelial ovarian carcinoma:(820.92±1053.28)u/mL,95%CI 484.06～1157.78 u/mL.There is significant difference between ① and ③,① and ④,② and ④,③ and ④(P <0.05);but no significant difference between ① and ②,② and ③(P >0.05).[Conclusion] The effect of CA125 in the differentiation of ovarian mass is clear.CA125 of epithelial ovarian carcinoma is significantly higher than overian benign leision and inflammatory leision.But we cannot differentiate inflammatory leision from benign leision and ovarian endometriosis cyst.The characteristic of mass can be guessed,which is helpful for treatment,but the clinical characteristics and other examination results should be taken into our minds to give the accurate diagnosis,avoiding mis-diagnosis and mis-treatment.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2007年第8期995-998,共4页
China Journal of Modern Medicine
关键词
CA125
卵巢癌
鉴别诊断
CA125
ovarian carcinoma
differentiatial diagnosis
