摘要
新型冠状病毒(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)流行期间执行的非药物干预(non-pharmaceutical interventions,NPIs)能够有效阻断疫情扩散。在减少SARS-CoV-2传播的同时,NPIs也减少了儿童与其他病原体的接触,使许多病毒和细菌感染发病率下降。病毒和细菌接触的减少以及SARS-CoV-2流行期间常规免疫接种的延迟或中断使人群免疫刺激不足,易感人群增加,导致群体免疫下降,形成了SARS-CoV-2流行期间的免疫债。在减少或取消实施NPIs后,部分病毒和细菌感染的发生率明显高于SARS-CoV-2流行前。现就SARS-CoV-2流行期间免疫债的定义、来源、影响及应对策略进行阐述,以提高临床医师对免疫债的关注和认识,优化儿童感染性疾病的预防。
Non-pharmaceutical interventions(NPIs)implemented during the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)epidemic have been proven to be effective in blocking the spread of the epidemic.While reducing SARS-CoV-2 transmission,NPIs also reduce children exposure to other pathogens,leading to a decline in the incidence of many viral and bacterial infections.The reduction in contact with viruses and bacteria and the delay or interruption of routine immunization during SARS-CoV-2 epidemic have resulted in insufficient immune stimulation of pathogens on the population,leading to an increase in susceptible populations and a decline in herd immunity,forming the immune debt during SARS-CoV-2 epidemic.After reducing or lifting NPIs,the incidence of some viral or bacterial infectious diseases was significantly higher than pre-epidemic.In this review,the definition,source,impact and strategies of immune debt during epidemic period were expounded,inorder to improve clinicians′attention and understanding of immune debt and optimize the prevention of children′s infectious diseases.
作者
韩鹏
郑跃杰
杨永弘
申昆玲
Han Peng;Zheng Yuejie;Yang Yonghong;Shen Kunling(Department of Respiratory,Beijing Children′s Hospital,Capital Medical University,China National Clinical Research Center of Respiratory Diseases,National Center for Children′s Health,Beijing 100045,China;Department of Respiratory,Shenzhen Children′s Hospital,Shenzhen 518038,China;Beijing Pediatric Research Institute,Beijing Children′s Hospital,Capital Medical University,National Clinical Research Center for Respiratory Disease,National Center for Children′s Health,Beijing 100045,China)
出处
《中华实用儿科临床杂志》
CAS
CSCD
北大核心
2023年第1期4-9,共6页
Chinese Journal of Applied Clinical Pediatrics
关键词
新型冠状病毒
非药物干预
免疫债
儿童
Severe acute respiratory syndrome coronavirus 2
Non-pharmaceutical intervention
Immune debt
Child
