摘要
神经病理性疼痛是由神经系统的原发性损害和神经功能障碍所引起的一种常见的、顽固性的慢性疼痛,临床主要表现为自发性疼痛、痛觉过敏、痛觉超敏等。其病因及发病机制尚未明确,临床亦缺乏确切有效的治疗方法。作为我国传统的疾病治疗手段,已经初步证实针刺主要是通过促进内源性阿片肽释放、抑制P物质含量、干扰腺苷代谢及调控嘌呤信号通路等来实现其镇痛作用。同时,临床研究中针刺在治疗脑卒中后疼痛、幻肢痛、脊髓损伤后疼痛、带状疱疹后疼痛、三叉神经痛、腕管综合征等中枢神经系统及周围神经系统疼痛疾病中取得了一定疗效。该文通过对近10年针刺治疗神经病理性疼痛的临床研究进展进行回顾分析,以期为科学研究和临床实践提供思路和有益参考。
Neuropathic pain is a common and intractable chronic disease triggered by primary damage of nervous system and neurological dysfunction.Its main clinical manifestations are spontaneous pain,hyperalgesia,allodynia and so on.However,the etiology and pathogenesis of this disease are not clear,and there is a lack of accurate and effective treatment in clinic practice.As a traditional method in China,it has been preliminarily confirmed that acupuncture achieves analgesic effect mainly by promoting the release of endogenous opioid peptide,inhibiting the signaling pathway of substance P,interfering adenosine metabolism and regulating the purine signaling pathway.Meanwhile,acupuncture has achieved certain efficacy in the treatment of central and peripheral nervous system,including central post-stroke pain,phantom limb pain,spinal cord injury,postherpetic neuralgia,trigeminal neuralgia,carpal tunnel syndrome and so on.This manuscript reviewed the clinical research progress of acupuncture on neuropathic pain in the past decades,therefore,providing clinical references for scientific research and clinical practice.
作者
陈亚媛
王舒娅
高昕妍
CHEN Yayuan;WANG Shuya;GAO Xinyan(Shaanxi University of Traditional Chinese Medicine,Xianyang 712046,Shaanxi,China;Institute of Acupuncture and Moxibustion,CACMS,Beijing 100700,China)
出处
《辽宁中医杂志》
CAS
2021年第7期244-247,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
国家自然科学基金(81473778,81804210)
关键词
针刺治疗
镇痛
神经病理性疼痛
中枢神经系统
周围神经系统
acupuncture therapy
analgesic effect
neuropathic pain
central nervous system
peripheral nervous system
