摘要
尽管可感染人的冠状病毒(human-infecting coronaviruses,HCo Vs)已经被发现了数十年,它们的临床重要性和流行潜能直到严重急性呼吸综合征(severe acute respiratory syndrome,SARS)和中东呼吸综合征(Middle East respiratory syndrome,MERS)的暴发才被重视。已鉴定出7种可感染人的冠状病毒,其中包括α-冠状病毒HCo V-NL63和HCo V-229E以及β-冠状病毒HCo V-OC43、HCo V-HKU1、严重急性呼吸综合征冠状病毒(severe acute respiratory syndrome coronavirus,SARS-Co V)、中东呼吸综合征冠状病毒(Middle East respiratory syndrome coronavirus,MERS-Co V)和2019新型冠状病毒(2019 novel coronavirus,2019-n Co V)。HCo Vs作为呼吸道感染的重要病原体,会导致人类中、重度呼吸道和肠道感染。特别是新型冠状病毒肺炎(coronavirus disease 2019,COVID-19)形成全球大流行,对公共卫生造成严重威胁。现对7种HCo Vs感染的流行病学、发病机制、临床特点及诊治进展等方面进行综述。
Although human-infecting coronaviruses(HCo Vs)have been identified for decades,their clinical importance and epidemic potential were not recognized until the outbreak of severe acute respiratory syndrome(SARS)and Middle East respiratory syndrome(MERS).Seven HCo Vs,including alpha coronavirus HCo V-NL63 and HCo V-229 E,beta coronavirus HCo V-OC43,HCo V-HKU1,severe acute respiratory syndrome coronavirus(SARS-Co V),Middle East respiratory syndrome coronavirus(MERS-Co V)and 2019 novel coronavirus(2019-n Co V),have been identified.As an important pathogen of respiratory tract infection,HCo Vs can cause moderate to severe respiratory and intestinal tract infection.In particular,coronavirus disease 2019(COVID-19)has become a global pandemic and seriously threatens public health.This review focuses on the epidemiology,the pathogenesis,the clinical characteristics as well as the diagnosis and treatment progress of seven HCo Vs infection.
作者
向晓辉
李美朝
李海
刘勇
XIANG Xiao-hui;LI Mei-zhao;LI Hai;LIU Yong(Department of Gastroenterology,Tianjin Xiqing Hospital,Tianjin 300380,China)
出处
《武警后勤学院学报（医学版）》
CAS
2020年第7期61-67,共7页
Journal of Logistics University of PAP（Medical Sciences）
基金
天津市自然科学基金项目(17JCYBJC26700)
