摘要
熊果酸(ursolic acid,UA)是广泛存在于夏枯草、女贞子等多种药用植物中的一种五环三萜类化合物,具有多种生物学效应。代谢综合征是以胰岛素抵抗为主,包括血脂异常、高血压、高血粘、葡萄糖稳态失调等为特征的一类代谢障碍疾病,已经成为严重的世界性健康问题。体内外研究表明,熊果酸可有效改善糖脂代谢紊乱,提高胰岛素敏感性,调节代谢相关酶类的表达,进而改善肥胖、动脉粥样硬化、糖尿病以及延缓NAFLD(Nonalcoholic Fatty Liver Disease)进展等,且对正常细胞毒性低,是一种理想的天然抗代谢综合征候选药物。现综合国际文献报道,对熊果酸对代谢综合征的作用研究进展进行综述。
Ursolic acid is a naturally plant-derived pentacyclic triterpenotid that is commonly found in various medicinal herbs and fruits,which attracted clinical interest due to its various beneficial pharmacological properties.Metabolic syndrome is a kind of metabolic disorder characterized by insulin resistance,dyslipidemia,hyperviscosemia and glucose homeostasis,which is a serious global problem of public health.An increasing amount of evidence in vivo and in vitro have shown that ursolic acid has low cytotoxicity to normal cells,but can effectively modulate a set of pathological symptom of metabolic syndrome like dyslipidemia and insulin resistance,regulate the activity and expression of metabolism-related enzymes,thereby delay the progression of abdominal obesity,atherosclerosis,diabetes and NAFLD.It is a potential natural candidate drug for anti-metabolic syndrome.This review focuses on some of the most recent researches that demonstrate the anti-metabolic syndrome effect and mechanism of ursolic acid.
作者
马素丽
刘冉
王继红
Ma Suli;Liu Ran;Wang Jihong(School of Medicine,Pingdingshan University,Henan,467000,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2020年第7期2578-2582,共5页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
河南省教育科学规划课题(〔2018〕-JKGHYB-0238):基于“岗位胜任力”的应用型护理本科人才培养模式研究,负责人:王福安
河南省卫生和计划生育委员会课题(WjIx2018234):课程思政引领下基护教学改革研究,负责人:郭耀玲
河南省卫生和计划生育委员会课题(WjIx2018236):新媒体环境下培养护生实践能力的效果研究,负责人:王继红
关键词
熊果酸
代谢综合征
进展
Ursolic acid
Metabolic syndrome
Review
