摘要
脑卒中后,学习与记忆障碍严重影响患者的功能康复与生活,临床观察发现耳迷走神经刺激能有效改善脑卒中后学习与记忆障碍症状。本研究从耳迷走神经刺激改善脑卒中后学习与记忆障碍,分析耳迷走神经刺激相关症状的可能机制,探讨确立耳穴-海马突触可塑性联系途径理论的可能,分析耳迷走神经刺激对脑卒中后学习与记忆障碍预后的调控机制,为提高耳迷走神经刺激治疗脑卒中后,学习与记忆障碍的临床疗效提供生理学证据支持,进一步促进耳迷走神经刺激疗法在脑卒中后功能康复进程中的应用。
Post-stroke learning or memory disorders severely affect the functional rehabilitation and life of patients.Clinical observations have found that transcutaneous auricular vagus nerve stimulation could effectively improve the symptoms of post-stroke learning or memory disorders.We have analyzed the mechanism of ta-VNS to improve learning or memory impairment after stroke by Eph/ephrin signaling pathway,and explore the possibility of establishing a pathway of auricular-hippocampal synaptic plasticity.To provide physiological evidences to improve the clinical efficacy of ta-VNS in the treatment of learning or memory disorders after stroke.
作者
赵敬军
王正辉
周立群
张金铃
荣培晶
Zhao Jingjun;Wang Zhenghui;Zhou Liqun;Zhang Jinling;Rong Peijing(Rehabilitation Medical College of Shanghai Traditional Chinese Medicine University,Shanghai 201203,China;The First Affiliated Hospital of Xinxiang Medical University,Xinxiang 453100,China;Wudang Medical Research Institute,Beijing University of Chinese Medicine,Beijing 100029,China;Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences,Beijing 100700,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2020年第7期2135-2139,共5页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委员会青年项目(81704163):基于NO-cGMP/PKG-pCREB信号通路研究耳迷走神经刺激促进缺血性脑卒中后运动功能重建的作用机制,负责人:赵敬军
国家自然科学基金中德合作研究项目(GZ1236):Purine signaling in depression and antidepressant effect of transcutaneous auricular vagus electroacupuncture,负责人:荣培晶
关键词
脑卒中后学习与记忆障碍
针刺
耳迷走神经刺激
作用机制
Post-stroke Learning and Memory Disorders
Acupuncture
Transcutaneous auricular Vagus Nerve Stimulation
Mechanism
