摘要
发热是机体在病原体入侵时所产生的一种复杂的防御性反应,对生物的生存意义重大。同时,发热作为炎症反应的主要标志之一,是科研工作者的重点研究对象。脂多糖(Lipopolysaccharide,LPS)诱导大鼠发热模型常用于解热药物研究中,但不同研究者所得的结果有较大差别。本文就LPS致大鼠发热的特点与机制方面的研究进展进行了整理,以期对发热模型建立以及解热实验研究提供一些帮助。
Fever is a complex defensive reaction when the body is invaded by pathogen,and has an important significance in the biological survival.At the same time,fever,as one of the main signs of inflammatory response,is the focus of researchers.LPS-induced rat fever models are commonly used in antipyretic studies,but the results obtained by different investigators are often quite different.In this paper,the research progress of the characteristics and mechanism of fever are discussed and summarized to provide some help in fever model building and antipyretic experimental studies.
作者
杨彪
胡玉梅
刘文君
姜涛
耿婷
曹亮
王振中
肖伟
Yang Biao;Hu Yumei;Liu Wenjun;Jiang Tao;Geng Ting;Cao Liang;Wang Zhenzhong;Xiao Wei(Jiangsu kanion Parmaceutical Co.,Ltd.,Lianyungang 222001,China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process,Lianyungang 222001,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2020年第7期2198-2204,共7页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
江苏省青年基金委员会项目(BK20180268):结合中西医理论研究七味通痹口服液治疗类风湿性关节炎的药效物质基础研究,负责人:耿婷
关键词
脂多糖
发热
特点
机制
Lipopolysaccharide
Fever
Characteristic
Mechanis
