摘要
目的2013~2019年本院儿童患者金黄色葡萄球菌的分布及耐药变迁情况,为临床提供可靠治疗依据。方法选回顾性分析本院2013年1月至2019年12月儿童患者的金黄色葡萄球菌分布情况及耐药性,使用VITEK2 Compact分析仪进行鉴定及做药敏。结果799株金黄色葡萄球菌集中的主要年龄段在29 d至<1岁和7岁至<18岁,分别占37.5%和33.1%,耐甲氧西林金黄色葡萄球(MRSA)检出率高的年龄为3岁至<7岁,占22.1%;金黄色葡萄球菌分布前3位的是儿内科、骨科、耳鼻喉科,分别占38.9%、14.5%、11.9%,MRSA检出率前3位的科室为心胸外科(22.2%)、泌尿外科(22.2%)、ICU(20.6%)。分离的主要标本是痰液(33.0%),其次为分泌物(31.7%)、脓液(21.0%)及全血(11.2%)。菌株中检出MRSA为125株,检出率为15.6%。耐药率高的抗菌药物分别为青霉素(90.9%)、红霉素(65.0%)、氯林霉素(54.0%)、苯唑青霉素(15.1%)、四环素(10.8%),对其余抗菌药物敏感性高;未检出对喹奴普汀/达福普汀、万古霉素、利奈唑胺、替加环素耐药的菌株。。结论本院儿童患者金黄色葡萄球菌对甲氧西林敏感的金黄色葡萄球菌(MSSA)为主,总耐药率低,但MRSA有上升趋势,临床医师予以重视。
Objective To analyze the distribution and drug resistance changes of Staphylococcus aureus in children in our hospital from 2013 to 2019,and provide a reliable basis for clinical treatment.Methods The distribution and drug resistance changes of Staphylococcus aureus in children patients in our hospital from January 2013 to December 2019 were analyzed retrospectively,VITEK2 Compact analyzer was used for identification and drug susceptibility testing.Results The 799 strains of Staphylococcus aureus were mainly concentrated in the age group from 29 days to<1 year old and from 7 to<18 years old,accounting for 37.5%and 33.1%,respectively.The age group with high detection rate of methicillin-resistant staphylococcus aureus(MRSA)was from 3 to<7 years old,accounting for 22.1%.The top 3 departments of Staphylococcus aureus distribution were pediatric internal medicine department,orthopedics,and otolaryngology,accounting for 38.9%,14.5%,and 11.9%respectively.The top 3 departments of MRSA detection rate were cardiothoracic surgery(22.2%),urology(22.2%),and ICU(20.6%).The main samples isolated were sputum(33.0%),followed by secretions(31.7%),pus(21.0%)and whole blood(11.2%).125 strains of MRSA were detected among the strains,and the detection rate was 15.6%.The antibacterial drugs with high drug resistance rate were penicillin(90.9%),erythromycin(65.0%),clindamycin(54.0%),oxacillin(15.1%)and tetracycline(10.8%),and they were highly sensitive to other antibacterial drugs.No strains resistant to Quinupristin/dalfopristin,vancomycin,linezolid,and tigecycline were detected.Conclusion Staphylococcus aureus is mainly methicillin-sensitive Staphylococcus aureus(MSSA)in children patients in our hospital,and the total drug resistance rate is low,but MRSA has an increasing trend,clinicians should pay attention to it.
作者
贝力克孜·艾合坦木
比德力克孜·热依木
阿不都亥力力·依马木
Beilikezi Aihetanmu;Bidelikezi Reyimu;Abuduhailili Yimamu(The First People’s Hospital of Aksu region,Aksu 843000,Xinjiang,China)
出处
《新疆医学》
2021年第7期787-791,共5页
Xinjiang Medical Journal
关键词
金黄色葡萄球菌
耐药
儿童
Staphylococcus aureus
drug resistance
children
