摘要
目的回顾性分析我市无偿献血血液筛查情况,在保障血液安全的前提下,调整ALT筛查阈值,降低献血前初筛淘汰和献血后检测报废,为制定更为优化的血液筛查策略提供依据。方法分析2016年1月1日~2018年12月31日献血前初筛159988人次、献血后检测137113份标本各项不合格占比;分层抽取献血前500份ALT初筛值进行百分位数分析,确定ALT筛查阈值;献血前、后提高阈值结果进行卡方分析;献血后ALT筛查不合格135人和其中47人再次献血两组检测结果追踪分析。结果1)献血前ALT初筛不合格占总不合格80.95%(18517/22875);献血后ALT检测不合格占总不合格11.43%(135/1181)。2)百分位数法(P_(95)=82)取整数确定ALT≤80U/L为阈值。3)献血前、后ALT阈值由≤50 u/L调整为≤80 U/L为合格,统计结果显示具有明显统计学意义。4)献血后ALT不合格135份HBsAg、抗-HCV检测结果均为合格,追踪其中47例再次献血各项检测结果均合格。结论ALT筛查不合格是献血人群不合格的主要因素,献血前ALT初筛不合格占比最大;献血前、后提高ALT阈值可增加9.81%的血源和减少0.06%血液报废;ALT筛查不合格与HBV、HCV感染无相关性。
Objective To retrospectively analyze the blood screening of unpaid blood donations in our city,adjust alanine transaminase(ALT)screening threshold under the premise of ensuring blood safety,reduce the preliminary screening and elimination of blood before donation and test scrapped after blood donation,and provide a basis for formulating more optimized blood screening strategies.Methods Analyzed the Proportion of each unqualified of 159988 person-times before blood donation from January 1,2016 to December 31,2018,and 137,113 specimens after blood donation.Through stratified sampling method,ALT preliminary screening values for 500 specimens prior to blood donation were analyzed in percentage terms to confirm ALT screening thresholds;raised the threshold result before and after blood donation to perform chi-square analysis.After blood donation,135 people failed the ALT screening and 47 of them donated blood again.The results of the two groups were traced and analyzed.Results 1)Prior to blood donation,the ALT screening disqualified accounted for 80.95%of the total disqualified(18517/22875);after blood donation,the ALT screening disqualified accounted for 11.43%(135/1181)of the total disqualified.2)Based on percentile analysis(P_(95)=82),round numbers were selected,confirming that ALT≤80 U/L were seen as threshold value.3)Prior to and after blood donation,ALT threshold was adjusted from≤50 u/L to≤80 U/L as qualified.There were statistically significant differences.4)After blood donation,135 disqualified ALT cases were discovered while HBsAg and anti-HCV detection results were qualified.47 cases of re-blood donation were traced and all the test results were qualified.Conclusion ALT screening unqualified are the major factors for the disqualified blood donation specimens.Prior to blood donation,proportion of donors with disqualified ALT is the highest;before and after donation,9.81%of blood resources can be improved and 0.06%of blood scrap can be reduced by the increases of ALT thresholds;disqualified ALT screening has no correlation with HBV and HCV infection.
作者
秦强国
张国平
QIN Qiangguo;ZHANG Guoping(Jiaozuo Central Blood Station,Jiaozuo 454000,Henan,China)
出处
《新疆医学》
2021年第7期798-801,共4页
Xinjiang Medical Journal
