摘要
目的检测孕妇尿液中环境内分泌干扰物邻苯二甲酸酯(phthalate acid esters,PAEs)代谢物的水平,并分析其与孕期抑郁的关系。方法连续收集100名孕妇的尿液,采用固相萃取-高效液相色谱法测定孕妇尿液中四种PAEs代谢产物的水平;采用基线资料调查表,抑郁自评量表(self-rating depression scale,SDS)对孕妇进行问卷调查。结果100名孕妇中,非抑郁者64人,抑郁者36人;尿液中4种PAEs代谢物检出率由高到低依次是邻苯二甲酸单丁酯(MBP)(90.00%)、邻苯二甲酸乙酯(MEP)(88.00%)、邻苯二甲酸单苄基酯(MBzP)(85.00%)、邻苯二甲酸单甲酯(MMP)(70.00%),其中MEP的浓度(215.31μg/L)最高,其次是MMP(83.02μg/L)、MBzP(31.75μg/L)、MBP(26.82μg/L);孕妇体内MBP水平与抑郁有关,OR(95%CI)为3.45(1.07~11.05)。结论孕期PAEs的暴露水平较高,孕期抑郁的发生与环境内分泌干扰物相关。
Objective To elucidate the association between phthalate and depression of women during pregnancy.This study aimed to measure the levels of environmental endocrine disrupting chemicals phthalate metabolites in urine of pregnant women,and analyze the relationship between phthalate metabolites and depression.Methods Urine samples of 100 pregnant women were collected and levels of four phthalate monoesters(PAEs)were measured using solid-phase extraction(SPE)-high performance liquid chromatography(HPLC).Meanwhile,a survey was conducted using a baseline data questionnaire and Self-Rating Depression Scale(SDS).Results Among 100 pregnant women,36 women had depression.The detection rate of four PAEs in urine was the highest of 90.00%for MBP(90.00%),followed by MEP(88.00%),MBzP(85.00%)and MMP(70.00%).The concentration of MEP was the highest of 215.31μg/L,followed by MMP(83.02μg/L),MBzP(31.75μg/L)and MBP(26.82μg/L).The level of MBP was associated with depression in pregnant women with the OR of 3.45(95%CI:1.07-11.05).Conclusions The exposure levels of PAEs in urine of pregnant women are high,and the occurrence of depression during pregnancy is related to environmental endocrine disrupting chemicals.
作者
贺娟娟
常可为
魏俊妮
刘良坡
刘莎
HE Juan-juan;CHANG Ke-wei;WEI Jun-ni;LIU Liang-po;LIU Sha(School of Public Health,Shanxi Medical University,Taiyuan,Shanxi 030001,China)
出处
《中国预防医学杂志》
CAS
CSCD
2020年第7期726-731,共6页
Chinese Preventive Medicine
基金
国家自然科学基金资助项目(30901227)
山西省回国留学人员科研资助项目(2016-058)
山西省基础研究项目(201901D111206)
