China is the country most seriously affected by coal and gas outburst accidents, which not only has the largest number of outburst mines, but also has a large number of outburst times and intensity. China's annual...China is the country most seriously affected by coal and gas outburst accidents, which not only has the largest number of outburst mines, but also has a large number of outburst times and intensity. China's annual total number of outburst and average intensity of outburst are far higher than the average level of major coal-producing countries in the world. In order to prevent coal and gas outburst accidents, China actively adopts coal mine outburst prevention measures, but the coal mine outburst prevention cost in China is as high as 50-60 yuan /t, which brings great economic pressure to coal mines. During coal seam mining and roadway excavation, on the one hand, when the mining work destroys or disturbs the original gas balance state in the stratum, the high gas in the coal seam will desorb and drift to the space with lower air pressure, and enter the goaf;On the other hand, mining causes the stress redistribution of surrounding rock in stope and changes the structure of coal and rock mass, and then changes the accumulation mode and migration form of gas in coal and rock mass, forming a certain width of outburst elimination area. In order to reduce the cost of outburst prevention and make rational use of outburst elimination belt, many coal and gas outburst mines in China adopt gob-side entry driving. However, the protection effect and scope of mined-out areas to surrounding solid coal are still unclear, and the Detailed Rules for Prevention and Control of Coal and Gas Outburst requires that mining activities in coal seams must take measures to eliminate outburst danger. Therefore, it is urgent to scientifically investigate and study the scope of pressure relief protection in solid coal along the gob side, so as to provide scientific basis and technical support for driving along the gob side, improve the utilization rate of resources, ensure safety in production, and have good economic and social benefits.展开更多
研究旨在探讨孕早期外周血中白细胞分化抗原44(cluster of differentiation 44,CD44,后类同)和CD69表达水平与子痫前期(preeclampsia)发生的关联,并评估指标与病情严重程度及新生儿结局的相关性。采用回顾性研究方法,收集2018年1月1日至...研究旨在探讨孕早期外周血中白细胞分化抗原44(cluster of differentiation 44,CD44,后类同)和CD69表达水平与子痫前期(preeclampsia)发生的关联,并评估指标与病情严重程度及新生儿结局的相关性。采用回顾性研究方法,收集2018年1月1日至2023年12月31日期间于深圳大学第一附属医院(深圳市第二人民医院)收治的100例子痫前期孕妇作为子痫前期组,同期100例健康孕妇作为对照组;采集入组孕妇的年龄、建册身体质量指数(body mass index,BMI)、建册血压、入院时BMI、入院时血压、随机尿蛋白定量、妊娠天数及新生儿出生体质量等临床资料,并通过ELISA检测研究对象孕早期外周血中游离CD44和CD69的表达。结果显示,子痫前期组孕早期外周血游离CD44和CD69水平显著低于对照组(均P<0.001);多因素Logistic回归分析显示,在排除潜在混杂因素后,CD44和CD69仍显示出对子痫前期发生的独立影响(均P<0.001);此外,CD44和CD69的含量显著影响子痫前期病情的严重程度(均P<0.05);ROC曲线分析显示,CD44和CD69及联合检测预测子痫前期的曲线下面积(area under the curve,AUC)均超过0.7,说明疾病预测效能较好,且以联合预测最佳(AUC=0.968,P<0.001);在新生儿结局方面,孕早期外周血中游离CD44和CD69水平与新生儿出生体质量及妊娠天数呈正相关(均P<0.05)。由此,孕早期外周血中CD44和CD69的表达水平可作为预测子痫前期发生的潜在生物标志物,并可能对评估子痫前期病情严重程度及新生儿结局提供辅助信息,为临床制订个性化筛查及预防策略提供参考。展开更多
文摘China is the country most seriously affected by coal and gas outburst accidents, which not only has the largest number of outburst mines, but also has a large number of outburst times and intensity. China's annual total number of outburst and average intensity of outburst are far higher than the average level of major coal-producing countries in the world. In order to prevent coal and gas outburst accidents, China actively adopts coal mine outburst prevention measures, but the coal mine outburst prevention cost in China is as high as 50-60 yuan /t, which brings great economic pressure to coal mines. During coal seam mining and roadway excavation, on the one hand, when the mining work destroys or disturbs the original gas balance state in the stratum, the high gas in the coal seam will desorb and drift to the space with lower air pressure, and enter the goaf;On the other hand, mining causes the stress redistribution of surrounding rock in stope and changes the structure of coal and rock mass, and then changes the accumulation mode and migration form of gas in coal and rock mass, forming a certain width of outburst elimination area. In order to reduce the cost of outburst prevention and make rational use of outburst elimination belt, many coal and gas outburst mines in China adopt gob-side entry driving. However, the protection effect and scope of mined-out areas to surrounding solid coal are still unclear, and the Detailed Rules for Prevention and Control of Coal and Gas Outburst requires that mining activities in coal seams must take measures to eliminate outburst danger. Therefore, it is urgent to scientifically investigate and study the scope of pressure relief protection in solid coal along the gob side, so as to provide scientific basis and technical support for driving along the gob side, improve the utilization rate of resources, ensure safety in production, and have good economic and social benefits.
文摘研究旨在探讨孕早期外周血中白细胞分化抗原44(cluster of differentiation 44,CD44,后类同)和CD69表达水平与子痫前期(preeclampsia)发生的关联,并评估指标与病情严重程度及新生儿结局的相关性。采用回顾性研究方法,收集2018年1月1日至2023年12月31日期间于深圳大学第一附属医院(深圳市第二人民医院)收治的100例子痫前期孕妇作为子痫前期组,同期100例健康孕妇作为对照组;采集入组孕妇的年龄、建册身体质量指数(body mass index,BMI)、建册血压、入院时BMI、入院时血压、随机尿蛋白定量、妊娠天数及新生儿出生体质量等临床资料,并通过ELISA检测研究对象孕早期外周血中游离CD44和CD69的表达。结果显示,子痫前期组孕早期外周血游离CD44和CD69水平显著低于对照组(均P<0.001);多因素Logistic回归分析显示,在排除潜在混杂因素后,CD44和CD69仍显示出对子痫前期发生的独立影响(均P<0.001);此外,CD44和CD69的含量显著影响子痫前期病情的严重程度(均P<0.05);ROC曲线分析显示,CD44和CD69及联合检测预测子痫前期的曲线下面积(area under the curve,AUC)均超过0.7,说明疾病预测效能较好,且以联合预测最佳(AUC=0.968,P<0.001);在新生儿结局方面,孕早期外周血中游离CD44和CD69水平与新生儿出生体质量及妊娠天数呈正相关(均P<0.05)。由此,孕早期外周血中CD44和CD69的表达水平可作为预测子痫前期发生的潜在生物标志物,并可能对评估子痫前期病情严重程度及新生儿结局提供辅助信息,为临床制订个性化筛查及预防策略提供参考。
